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Evaluation of prognostic impact of pre-treatment neutrophil to lymphocyte and lymphocyte to monocyte ratios in dogs with oral malignant melanoma treated with surgery and adjuvant CSPG4-antigen electrovaccination: an explorative study.
Camerino, Mariateresa; Giacobino, Davide; Iussich, Selina; Ala, Ugo; Riccardo, Federica; Cavallo, Federica; Martano, Marina; Morello, Emanuela; Buracco, Paolo.
Afiliación
  • Camerino M; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
  • Giacobino D; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
  • Iussich S; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
  • Ala U; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
  • Riccardo F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, 10 University of Torino, Torino, Italy.
  • Cavallo F; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, 10 University of Torino, Torino, Italy.
  • Martano M; Department of Veterinary Sciences, University of Parma, Parma, Italy.
  • Morello E; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
  • Buracco P; Department of Veterinary Sciences, University of Torino, Grugliasco, Italy.
Vet Comp Oncol ; 19(2): 353-361, 2021 Jun.
Article en En | MEDLINE | ID: mdl-33443307
The role of systemic inflammation in cancer's progression has been widely investigated, especially in melanoma in humans. Pre-treatment leukocyte counts and ratios play a recognized prognostic role in several types of malignancies, but no information is available regarding canine oral malignant melanoma (COMM). The purpose of this explorative retrospective study was to investigate the prognostic impact of pre-treatment neutrophil to lymphocyte (NLR) and lymphocyte to monocyte (LMR) ratios in dogs with oral malignant melanoma that underwent surgical resection and immunotherapy with adjuvant CSPG4-antigen electrovaccination. Thirty-nine dogs with histologically confirmed oral melanoma and with available pre-treatment haematological analyses, performed at maximum 60 days before the first treatment, were retrospectively enrolled. Statistical analysis was performed to explore possible correlations among NLR and LMR with age, clinical stage, tumour pigmentation, tumour size, nuclear atypia, mitotic index, Ki67, CSPG4 expression, ulceration, bone invasion and excision margins status. The impact of NLR and LMR on overall survival time (OST) was explored among various ratio cut off and across different time points with Kaplan-Meier method. No significant relationship was identified between leukocytes ratios and histological parameters, CSPG4 expression, excision margin status, age, tumour size and clinical stage. NLR and LMR did not display a prognostic impact on the survival time of the entire population. Pre-treatment leukocyte ratios may not represent a useful prognostic factor in dogs with oral melanoma, especially in absence of distant metastatic disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Enfermedades de los Perros / Melanoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Enfermedades de los Perros / Melanoma Tipo de estudio: Observational_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Vet Comp Oncol Asunto de la revista: MEDICINA VETERINARIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido