Multi-stage screening to predict the specific anticancer activity of Ni(II) mixed-ligand complex on gastric cancer cells; biological activity, FTIR spectrum, DNA binding behavior and simulation studies.

Heidarpoor Saremi, Leily; Dadashi Noshahr, Karim; Ebrahimi, Ali; Khalegian, Ali; Abdi, Khatereh; Lagzian, Milad

Heidarpoor Saremi, Leily; Dadashi Noshahr, Karim; Ebrahimi, Ali; Khalegian, Ali; Abdi, Khatereh; Lagzian, Milad.

Afiliación

Heidarpoor Saremi L; Department of Chemistry, Computational Quantum Chemistry Laboratory, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
Dadashi Noshahr K; Semnan University of Medical Science, Faculty of Medicine, Medical Biotechnology Department, Semnan, Iran.
Ebrahimi A; Department of Chemistry, Computational Quantum Chemistry Laboratory, University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran. Electronic address: ebrahimi@chem.usb.ac.ir.
Khalegian A; Semnan University of Medical Science, Faculty of Medicine, Biochemistry Department, Semnan, Iran. Electronic address: khaleghian.ali@gmail.com.
Abdi K; Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.
Lagzian M; Department of Biology, Faculty of Sciences, University of Sistan and Baluchestan, Zahedan, Iran.

Spectrochim Acta A Mol Biomol Spectrosc ; 251: 119377, 2021 Apr 15.

Article en En | MEDLINE | ID: mdl-33440284

Asunto(s)

Antineoplásicos; Complejos de Coordinación; Neoplasias Gástricas; Antineoplásicos/farmacología; Complejos de Coordinación/farmacología; ADN; Detección Precoz del Cáncer; Humanos; Ligandos; Simulación del Acoplamiento Molecular; Espectroscopía Infrarroja por Transformada de Fourier; Neoplasias Gástricas/tratamiento farmacológico

Palabras clave

Anticancer properties; DNA binding; Docking; FTIR spectroscopy; MD simulations; NCI topological analysis; Ni(II) complex

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Complejos de Coordinación / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Humans Idioma: En Revista: Spectrochim Acta A Mol Biomol Spectrosc Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido

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