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Molecular cytopathology diagnosis of a lung neoplasm: Case report of an unusual non-small cell carcinoma with MET exon 14 skipping mutation.
Hosseini, S Mohsen; Khanafshar, Elham; Seeley, Eric J; Ruiz-Cordero, Roberto.
Afiliación
  • Hosseini SM; Division of Cytopathology, Department of Pathology, University of California, San Francisco, California, USA.
  • Khanafshar E; Division of Cytopathology, Department of Pathology, University of California, San Francisco, California, USA.
  • Seeley EJ; Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, California, USA.
  • Ruiz-Cordero R; Division of Cytopathology, Department of Pathology, University of California, San Francisco, California, USA.
Diagn Cytopathol ; 49(7): E258-E261, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33433963
Here we report the combined cytological and molecular diagnosis of a lung mass. The cytology and extensive immunohistochemistry on an endobronchial ultrasound-guided fine needle aspiration biopsy were inconclusive. By genomic profiling of the cell block material, we identified a MET exon 14 skipping mutation that indicated a lung origin and made the patient eligible for the tyrosine kinase inhibitor, crizotinib. This case is a prime example of complementing adequate aspiration and cell block processing techniques with molecular testing. Such an approach would augment the usability of fine needle aspiration biopsy, both as a diagnostic modality and as the first line to find therapeutic targets in the era of precision medicine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Proteínas Proto-Oncogénicas c-met / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans Idioma: En Revista: Diagn Cytopathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Proteínas Proto-Oncogénicas c-met / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Aged / Female / Humans Idioma: En Revista: Diagn Cytopathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos