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ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere, Arnaud; Blokx, Willeke; van Kempen, Léon C; Luzar, Bostjan; Piperno-Neumann, Sophie; Puig, Susana; Alos, Llucia; Calonje, Eduardo; Massi, Daniela.
Afiliación
  • de la Fouchardiere A; Department of Biopathology, Center Léon Bérard, Lyon, France.
  • Blokx W; Department of Pathology, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center, Utrecht, The Netherlands.
  • van Kempen LC; Faculty of Medical Sciences, University Medical Center Groningen, Department of Pathology & Medical Biology, University of Groningen, Groningen, The Netherlands.
  • Luzar B; Institute of Pathology, Medical Faculty University of Ljubljana, Ljubljana, Slovenia.
  • Piperno-Neumann S; Department of Medical Oncology, Institut Curie, 75005, Paris, France.
  • Puig S; EURACAN network member (rare skin and eye melanoma domain), Leiden, The Netherlands.
  • Alos L; Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Spain.
  • Calonje E; Institut d'Investigació Biomèdica August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
  • Massi D; Centro de Investigación Biomédica En Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain.
Virchows Arch ; 479(1): 3-11, 2021 Jul.
Article en En | MEDLINE | ID: mdl-33432480
The recent WHO classification of skin tumors has underscored the importance of acknowledging intermediate grade melanocytic proliferations. A multistep acquisition of oncogenic events drives the progressive transformation of nevi into melanomas. The various pathways described are modulated by the initial oncogenic drivers that define the common, blue, and Spitz nevi groups. Intermediate lesions are most often the result of a clonal evolution within such nevi. Based on this established classification, we have suggested for each pathway a practical diagnostic approach, benefiting from the recently developed molecular tools, both in the setting of general pathology labs and expert centers. Moreover, recommendations regarding the re-excision and clinical follow-up are given to support decision-making in multidisciplinary tumor boards.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Técnicas de Apoyo para la Decisión / Técnicas de Diagnóstico Molecular / Proliferación Celular / Melanocitos / Melanoma / Nevo Pigmentado Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Adult / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Técnicas de Apoyo para la Decisión / Técnicas de Diagnóstico Molecular / Proliferación Celular / Melanocitos / Melanoma / Nevo Pigmentado Tipo de estudio: Diagnostic_studies / Guideline / Prognostic_studies Límite: Adult / Female / Humans / Infant / Male / Middle aged Idioma: En Revista: Virchows Arch Asunto de la revista: BIOLOGIA MOLECULAR / PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania