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Colorimetric recognition of aromatic amino acid enantiomers by gluconic acid-capped gold nanoparticles.
Yang, Jiangxia; Li, Xiaoqi; Du, Yingxiang; Ma, Mingxuan; Zhang, Liu; Zhang, Jian; Li, Peipei.
Afiliación
  • Yang J; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
  • Li X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
  • Du Y; Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, People's Republic of China. xiaoqili8619@163.com.
  • Ma M; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China. du_yingxiang@126.com.
  • Zhang L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China. du_yingxiang@126.com.
  • Zhang J; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
  • Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, No.24 Tongjiaxiang, Nanjing, 210009, Jiangsu, People's Republic of China.
Amino Acids ; 53(2): 195-204, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33432455
In this work, we prepared gold nanoparticles (AuNPs) by employing gluconic acid (GlcA) as reducing-cum-stabilizing agent. The proposed GlcA-AuNPs successfully worked as a colorimetric sensor for visual chiral recognition of aromatic amino acid enantiomers, namely tyrosine (D/L-Tyr), phenylalanine (D/L-Phe), and tryptophan (D/L-Trp). After adding L-types to GlcA-AuNPs solution, the color of the mixture changed from red to purple (or gray), while no obvious color change occurred on the addition of D-types. The effect can be detected by naked eyes. The particles have been characterized by transmission electron microscopy, Fourier-transform infrared spectroscopy, zeta potential, the dynamic light scattering analysis as well as UV-Vis spectroscopy. This assay can be used to determine the enantiomeric excess of L-Trp in the range from 0 to + 100%. The method has advantages in simplicity, sensitivity, fast response, and low cost.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilalanina / Tirosina / Triptófano / Colorimetría Tipo de estudio: Evaluation_studies Idioma: En Revista: Amino Acids Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Austria
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenilalanina / Tirosina / Triptófano / Colorimetría Tipo de estudio: Evaluation_studies Idioma: En Revista: Amino Acids Asunto de la revista: BIOQUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Austria