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Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy.
Schuldt, Maike; Pei, Jiayi; Harakalova, Magdalena; Dorsch, Larissa M; Schlossarek, Saskia; Mokry, Michal; Knol, Jaco C; Pham, Thang V; Schelfhorst, Tim; Piersma, Sander R; Dos Remedios, Cris; Dalinghaus, Michiel; Michels, Michelle; Asselbergs, Folkert W; Moutin, Marie-Jo; Carrier, Lucie; Jimenez, Connie R; van der Velden, Jolanda; Kuster, Diederik W D.
Afiliación
  • Schuldt M; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, The Netherlands (M.S., L.M.D., J.v.d.V., D.W.D.K.).
  • Pei J; Division Heart and Lungs, Department of Cardiology (J.P., M.H., F.W.A.), University Medical Center Utrecht, The Netherlands.
  • Harakalova M; Division Heart and Lungs, Department of Cardiology (J.P., M.H., F.W.A.), University Medical Center Utrecht, The Netherlands.
  • Dorsch LM; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Physiology, Amsterdam Cardiovascular Sciences, The Netherlands (M.S., L.M.D., J.v.d.V., D.W.D.K.).
  • Schlossarek S; Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Germany (S.S., L.C.).
  • Mokry M; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany (S.S., L.C.).
  • Knol JC; Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital (M. Morky), University Medical Center Utrecht, The Netherlands.
  • Pham TV; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, OncoProteomics Laboratory, VUmc-Cancer Center Amsterdam, The Netherlands (J.C.K., T.V.P., T.S., S.R.P., C.R.J.).
  • Schelfhorst T; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, OncoProteomics Laboratory, VUmc-Cancer Center Amsterdam, The Netherlands (J.C.K., T.V.P., T.S., S.R.P., C.R.J.).
  • Piersma SR; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, OncoProteomics Laboratory, VUmc-Cancer Center Amsterdam, The Netherlands (J.C.K., T.V.P., T.S., S.R.P., C.R.J.).
  • Dos Remedios C; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Oncology, OncoProteomics Laboratory, VUmc-Cancer Center Amsterdam, The Netherlands (J.C.K., T.V.P., T.S., S.R.P., C.R.J.).
  • Dalinghaus M; Sydney Heart Bank, Discipline of Anatomy, Bosch Institute, University of Sydney, Australia (C.d.R.).
  • Michels M; Department of Pediatric Cardiology (M.D.), Erasmus Medical Center Rotterdam, The Netherlands.
  • Asselbergs FW; Department of Cardiology, Thorax Center (M. Michels), Erasmus Medical Center Rotterdam, The Netherlands.
  • Moutin MJ; Division Heart and Lungs, Department of Cardiology (J.P., M.H., F.W.A.), University Medical Center Utrecht, The Netherlands.
  • Carrier L; Institute of Cardiovascular Science, Faculty of Population Health Sciences (F.W.A.), University College London, United Kingdom.
  • Jimenez CR; Health Data Research UK and Institute of Health Informatics (F.W.A.), University College London, United Kingdom.
  • van der Velden J; Grenoble Institut des Neurosciences (GIN), Université Grenoble Alpes, Grenoble, France (M.-J.M.).
  • Kuster DWD; Institute of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, Germany (S.S., L.C.).
Circ Heart Fail ; 14(1): e007022, 2021 01.
Article en En | MEDLINE | ID: mdl-33430602
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Tubulina (Proteína) / Cardiomiopatía Hipertrófica / Obstrucción del Flujo Ventricular Externo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Circ Heart Fail Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tirosina / Tubulina (Proteína) / Cardiomiopatía Hipertrófica / Obstrucción del Flujo Ventricular Externo Tipo de estudio: Observational_studies / Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Circ Heart Fail Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos