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Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction.
Sun, Jie; Qiao, Yan-Ning; Tao, Tao; Zhao, Wei; Wei, Li-Sha; Li, Ye-Qiong; Wang, Wei; Wang, Ye; Zhou, Yu-Wei; Zheng, Yan-Yan; Chen, Xin; Pan, Hong-Chun; Zhang, Xue-Na; Zhu, Min-Sheng.
Afiliación
  • Sun J; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Qiao YN; Key Laboratory of MOE for Modern Teaching Technology, Shaanxi Normal University, Xi'an, China.
  • Tao T; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Zhao W; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Wei LS; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Li YQ; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Wang W; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Wang Y; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Zhou YW; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Zheng YY; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Chen X; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Pan HC; College of Life Sciences, Anhui Normal University, Wuhu, China.
  • Zhang XN; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
  • Zhu MS; Model Animal Research Center, School of Medicine, Nanjing University, Nanjing, China.
Front Physiol ; 11: 593966, 2020.
Article en En | MEDLINE | ID: mdl-33424621
Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined. In this report, we assessed their roles by analyzing mice deficient of Myl9, a gene encoding the SM myosin regulatory light chain (SM RLC). We find that global Myl9-deficient bladders contracted with an apparent sustained phase, despite no initial phase. This sustained contraction was mediated by NM myosin RLC (NM RLC) phosphorylation by myosin light chain kinase (MLCK). NM myosin II was expressed abundantly in the uterus and young mice bladders, of which the force was accordingly sensitive to NM myosin inhibition. Our findings reveal distinct roles of SM RLC and NM RLC in SM contraction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Physiol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza