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Evaluating totipotency using criteria of increasing stringency.
Posfai, Eszter; Schell, John Paul; Janiszewski, Adrian; Rovic, Isidora; Murray, Alexander; Bradshaw, Brian; Yamakawa, Tatsuya; Pardon, Tine; El Bakkali, Mouna; Talon, Irene; De Geest, Natalie; Kumar, Pankaj; To, San Kit; Petropoulos, Sophie; Jurisicova, Andrea; Pasque, Vincent; Lanner, Fredrik; Rossant, Janet.
Afiliación
  • Posfai E; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada. eposfai@princeton.edu.
  • Schell JP; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. eposfai@princeton.edu.
  • Janiszewski A; Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Rovic I; Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
  • Murray A; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Bradshaw B; Lunenfeld Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
  • Yamakawa T; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Pardon T; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • El Bakkali M; Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.
  • Talon I; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • De Geest N; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Kumar P; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • To SK; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Petropoulos S; Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Jurisicova A; Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
  • Pasque V; Department of Development and Regeneration, Leuven Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Lanner F; Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
  • Rossant J; Division of Obstetrics and Gynecology, Karolinska Universitetssjukhuset, Stockholm, Sweden.
Nat Cell Biol ; 23(1): 49-60, 2021 01.
Article en En | MEDLINE | ID: mdl-33420491
Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that build the conceptus, yet how to capture this property in vitro remains incompletely understood. Defining totipotency relies on a variety of assays of variable stringency. Here, we describe criteria to define totipotency. We explain how distinct criteria of increasing stringency can be used to judge totipotency by evaluating candidate totipotent cell types in mice, including early blastomeres and expanded or extended pluripotent stem cells. Our data challenge the notion that expanded or extended pluripotent states harbour increased totipotent potential relative to conventional embryonic stem cells under in vitro and in vivo conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Blastómeros / Diferenciación Celular / Linaje de la Célula / Células Madre Pluripotentes / Células Madre Totipotentes / Embrión de Mamíferos / Células Madre Embrionarias Límite: Animals Idioma: En Revista: Nat Cell Biol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Blastómeros / Diferenciación Celular / Linaje de la Célula / Células Madre Pluripotentes / Células Madre Totipotentes / Embrión de Mamíferos / Células Madre Embrionarias Límite: Animals Idioma: En Revista: Nat Cell Biol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido