[Toxic hydroxychloroquine-induced cardiomyopathy complicating systemic lupus treatment]. / Cardiomyopathie toxique induite par l'hydroxychloroquine compliquant le traitement d'un lupus systémique.
Ann Pathol
; 41(1): 101-104, 2021 Feb.
Article
en Fr
| MEDLINE
| ID: mdl-33419598
Hydroxychloroquine (HCQ) is considered as efficient and safe to treat systemic lupus. We report a case of fatal toxic cardiomyopathy, an underrecognized adverse effect of HCQ. A 72-year-old woman with systemic lupus erythematosus treated for 24 years by HCQ received a kidney allograft. One year later she developed a cardiomyopathy with conductive disorders. An endomyocardial biopsy showed severe non-specific myocardial fibrosis and hypertrophic vacuolated myocytes. Transmission electron microscopy showed curvilinear bodies and pseudomyelin figures consistent with HCQ-induced cardiomyopathy. At immunohistochemistry LC3b, p62 and beclin-1 accumulated in vacuolated cardiac myocytes suggesting impaired cell autophagy. When unexplained cardiac disease develops in patients receiving long-term HCQ treatment, toxic cardiomyopathy should be considered leading to a diagnostic endomyocardial biopsy.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lupus Eritematoso Sistémico
/
Cardiomiopatías
Límite:
Aged
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Female
/
Humans
Idioma:
Fr
Revista:
Ann Pathol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia