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The hippocampal region is necessary for text comprehension and memorization: a combined VBM/DTI study in neuropsychological patients.
Hausser, Lucile P; Bugaud, Agathe; Noblet, Vincent; de Sousa, Paulo Loureiro; Botzung, Anne; Blanc, Frédéric; Bernard, Frédéric A.
Afiliación
  • Hausser LP; ICube Laboratory (UMR 7357), University of Strasbourg and CNRS, Strasbourg, France.
  • Bugaud A; ICube Laboratory (UMR 7357), University of Strasbourg and CNRS, Strasbourg, France.
  • Noblet V; ICube Laboratory (UMR 7357), University of Strasbourg and CNRS, Strasbourg, France.
  • de Sousa PL; ICube Laboratory (UMR 7357), University of Strasbourg and CNRS, Strasbourg, France.
  • Botzung A; Geriatrics Day Hospital and Neuropsychology Unit, Geriatrics Department and Neurology Service, Memory Resources and Research Centre (CM2R), University Hospital of Strasbourg, Strasbourg, France.
  • Blanc F; ICube Laboratory (UMR 7357), University of Strasbourg and CNRS, Strasbourg, France.
  • Bernard FA; Geriatrics Day Hospital and Neuropsychology Unit, Geriatrics Department and Neurology Service, Memory Resources and Research Centre (CM2R), University Hospital of Strasbourg, Strasbourg, France.
Brain Imaging Behav ; 15(5): 2367-2376, 2021 Oct.
Article en En | MEDLINE | ID: mdl-33415514
According to the Construction-Integration model (Kintsch 1988; Kintsch 1998), two forms of representation are activated during the reading and the comprehension of a text: 1) the text base, which includes semantic propositions and 2) the situation model, corresponding to the integration of the information contained in the text to the memories and knowledge of the reader. Functional neuroimaging studies in healthy subjects have shown that the text base is underpinned by frontal regions and lateral temporal regions whereas the situation model would rather depend on the posterior cingulate cortex, the precuneus and other regions depending on the dimension studied. However, the brain regions highlighted so far were only involved in comprehension and not necessary for this cognitive ability. For the first time, we explored the brain structures necessary to understand texts using a combined VBM/DTI approach in neuropsychological patients with whom we obtained comprehension scores (text base and situation model) after the reading of narrative texts. To our great surprise and contrary to our hypotheses, which were based on the results of functional neuroimaging studies, our own results show that it is the hippocampal region that is necessary to activate and memorize/remember the text base and the situation model. The highlighting of a link between the integrity of a portion of the uncinate fasciculus which is well known to play a role in semantic processing and the performance scores of the text base suggests that the hippocampal region is necessary not only for the retrieval of the text base and of the situation model thanks to episodic memory, but also for the activation of the text base during the reading and the comprehension of a text.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Comprensión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Comprensión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Brain Imaging Behav Asunto de la revista: CEREBRO / CIENCIAS DO COMPORTAMENTO / DIAGNOSTICO POR IMAGEM Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos