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MiR-429 Involves in the Pathogenesis of Colorectal Cancer via Directly Targeting LATS2.
Chen, Xia; Wang, Ai-Li; Liu, Yuan-Yuan; Zhao, Chen-Xi; Zhou, Xue; Liu, Hai-Long; Lin, Mo-Bin.
Afiliación
  • Chen X; Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
  • Wang AL; Institute of Gastrointestinal Surgery and Translational Medicine, Tongji University School of Medicine, Shanghai 200090, China.
  • Liu YY; Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
  • Zhao CX; Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
  • Zhou X; Institute of Gastrointestinal Surgery and Translational Medicine, Tongji University School of Medicine, Shanghai 200090, China.
  • Liu HL; Department of General Surgery, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
  • Lin MB; Center for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai 200090, China.
Oxid Med Cell Longev ; 2020: 5316276, 2020.
Article en En | MEDLINE | ID: mdl-33414893
Colorectal cancer (CRC) is a leading cause of cancer-related death around the world whose recurrence and metastasis rate is high. Due to the underlying unclear pathogenesis, it is hard so far to predict the tumorigenesis and prevent its recurrence. YAP/TAZ has been reported to be activated and functioned as a potential oncogene in multiple cancer types and proved to be essential for the carcinogenesis of most solid tumors. In the present study, we found that YAP/TAZ was markedly upregulated in CRC tissues comparing with the adjacent noncancerous tissues due to the downregulation of LATS2, the main upstream regulator. We further identified miR-429 as a direct regulator of LATS2-YAP/TAZ activation, suggesting that the miR-429-LATS2-YAP/TAZ might be novel effective diagnostic axis and therapeutic targets for CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Serina-Treonina Quinasas / Proteínas Supresoras de Tumor / MicroARNs Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas Serina-Treonina Quinasas / Proteínas Supresoras de Tumor / MicroARNs Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos