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Ovarian stimulation for fertility preservation in an oncology patient with etonogestrel implant in place.
Rushing, John S; Appiah, Leslie; Polotsky, Alex J; Murray, Shona; Foust, Erin; Hassell, Kathryn; Roeca, Cassandra.
Afiliación
  • Rushing JS; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA. john.rushing@cuanschutz.edu.
  • Appiah L; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA.
  • Polotsky AJ; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA.
  • Murray S; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA.
  • Foust E; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA.
  • Hassell K; Department of Medicine, Anschutz Medical Campus, University of Colorado, Aurora, CO, USA.
  • Roeca C; Department of Obstetrics and Gynecology, Anschutz Medical Campus, University of Colorado, 12631 E 17th Ave Ste B198-6, Aurora, CO, 80045-2529, USA.
J Assist Reprod Genet ; 38(2): 513-516, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33409752
PURPOSE: To describe a case of a young woman who presented for fertility preservation and underwent ovarian stimulation with an etonogestrel implant in place. METHODS: A 24-year old, gravida 0, with an etonogestrel implant and newly diagnosed lower extremity sarcoma and DVT desiring oocyte cryopreservation prior to adjuvant chemotherapy and radiation. To avoid delay in her oncologic care and allow for continued use of contraception post-retrieval, the patient underwent controlled ovarian hyperstimulation (COH) without removal of the etonogestrel implant. RESULTS: Baseline labs included follicle-stimulating hormone 9 mIU/mL, luteinizing hormone 4.9 mIU/mL, estradiol 42 pg/mL, anti-Müllerian hormone 5.1 ng/mL, and antral follicle count greater than 40. The patient was placed on an antagonist protocol and stimulated with 125 IU Gonal-F and 75 IU Menopur. She received a total of 12 days of gonadotropin stimulation. On the day of trigger, her estradiol was 1472 pg/mL, lead follicle 21.5 mm with a total of 25 follicles measured > 12 mm. She was triggered with 5000 U hCG. She had a total of 23 oocytes retrieved, 17 of which were metaphase II and vitrified. CONCLUSIONS: COH and successful oocyte cryopreservation can be achieved in patients with an etonogestrel implant in situ without apparent detrimental effects to oocyte yield or maturity. Due to the etonogestrel implant's inhibitory effects on LH, it is recommended to use an hCG trigger for final oocyte maturation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desogestrel / Preservación de la Fertilidad / Infertilidad Femenina / Neoplasias Tipo de estudio: Etiology_studies / Guideline Límite: Adult / Female / Humans Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desogestrel / Preservación de la Fertilidad / Infertilidad Femenina / Neoplasias Tipo de estudio: Etiology_studies / Guideline Límite: Adult / Female / Humans Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos