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Exercise reduces metabolic burden while altering the immune system in aged mice.
Yoon, Kyeong Jin; Ahn, Aram; Park, Soo Hong; Kwak, Seung Hee; Kwak, Seong Eun; Lee, Wonsang; Yang, Yong Ryoul; Kim, Minji; Shin, Hyun Mu; Kim, Hang-Rae; Moon, Hyo Youl.
Afiliación
  • Yoon KJ; Department of Physical Education, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Ahn A; Institute of Sport Science, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Park SH; Department of Kinesiology, University of Connecticut, Storrs, CT 06269,USA.
  • Kwak SH; Department of Physical Education, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Kwak SE; Institute of Sport Science, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Lee W; Department of Physical Education, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Yang YR; Institute of Sport Science, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Kim M; Department of Physical Education, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Shin HM; School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
  • Kim HR; Department of Physical Education, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
  • Moon HY; Institute of Sport Science, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul, Republic of Korea.
Aging (Albany NY) ; 13(1): 1294-1313, 2021 01 06.
Article en En | MEDLINE | ID: mdl-33406502
Although several evidence has suggested the impact of exercise on the prevention of aging phenotypes, few studies have been conducted on the mechanism by which exercise alters the immune-cell profile, thereby improving metabolism in senile obesity. In this study, we confirmed that 4-week treadmill exercise sufficiently improved metabolic function, including increased lean mass and decreased fat mass, in 88-week-old mice. The expression level of the senescence marker p16 in the white adipose tissue (WAT) was decreased after 4-weeks of exercise. Exercise induced changes in the profiles of immune-cell subsets, including natural killer (NK) cells, central memory CD8+ T cells, eosinophils, and neutrophils, in the stromal vascular fraction of WAT. In addition, it has been shown through transcriptome analysis of WAT that exercise can activate pathways involved in the interaction between WAT and immune cells, in particular NK cells, in aged mice. These results suggest that exercise has a profound effect on changes in immune-cell distribution and senescent-cell scavenging in WAT of aged mice, eventually affecting overall energy metabolism toward a more youthful state.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Metabolismo Energético / Esfuerzo Físico / Tejido Adiposo Blanco / Sistema Inmunológico Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condicionamiento Físico Animal / Metabolismo Energético / Esfuerzo Físico / Tejido Adiposo Blanco / Sistema Inmunológico Límite: Animals Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos