Your browser doesn't support javascript.
loading
CC Chemokine Receptor 2-Targeting Copper Nanoparticles for Positron Emission Tomography-Guided Delivery of Gemcitabine for Pancreatic Ductal Adenocarcinoma.
Zhang, Xiaohui; Detering, Lisa; Sultan, Deborah; Luehmann, Hannah; Li, Lin; Heo, Gyu Seong; Zhang, Xiuli; Lou, Lanlan; Grierson, Patrick M; Greco, Suellen; Ruzinova, Marianna; Laforest, Richard; Dehdashti, Farrokh; Lim, Kian-Huat; Liu, Yongjian.
Afiliación
  • Zhang X; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Detering L; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Sultan D; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Luehmann H; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Li L; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Heo GS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Zhang X; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Lou L; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Grierson PM; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Greco S; Division of Comparative Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Ruzinova M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Laforest R; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Dehdashti F; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Lim KH; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
  • Liu Y; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
ACS Nano ; 15(1): 1186-1198, 2021 01 26.
Article en En | MEDLINE | ID: mdl-33406361
Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy with dire prognosis due to aggressive biology, lack of effective tools for diagnosis at an early stage, and limited treatment options. Detection of PDAC using conventional radiographic imaging is limited by the dense, hypovascular stromal component and relatively scarce neoplastic cells within the tumor microenvironment (TME). The CC motif chemokine 2 (CCL2) and its cognate receptor CCR2 (CCL2/CCR2) axis are critical in fostering and maintaining this kind of TME by recruiting immunosuppressive myeloid cells such as the tumor-associated macrophages, thereby presenting an opportunity to exploit this axis for both diagnostic and therapeutic purposes. We engineered CCR2-targeting ultrasmall copper nanoparticles (Cu@CuOx) as nanovehicles not only for targeted positron emission tomography imaging by intrinsic radiolabeling with 64Cu but also for loading and delivery of the chemotherapy drug gemcitabine to PDAC. This 64Cu-radiolabeled nanovehicle allowed sensitive and accurate detection of PDAC malignancy in autochthonous genetically engineered mouse models. The ultrasmall Cu@CuOx showed efficient renal clearance, favorable pharmacokinetics, and minimal in vivo toxicity. Systemic administration of gemcitabine-loaded Cu@CuOx effectively suppressed the progression of PDAC tumors in a syngeneic xenograft mouse model and prolonged survival. These CCR2-targeted ultrasmall nanoparticles offer a promising image-guided therapeutic agent and show great potential for translation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Nanopartículas Límite: Animals Idioma: En Revista: ACS Nano Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Nanopartículas Límite: Animals Idioma: En Revista: ACS Nano Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos