Linking <i>In Vitro</i> Intrinsic Dissolution Rate and Thermodynamic Solubility with Pharmacokinetic Profiles of Bedaquiline Long-Acting Aqueous Microsuspensions in Rats.

Nguyen, Vy; Bevernage, Jan; Darville, Nicolas; Tistaert, Christophe; Van Bocxlaer, Jan; Rossenu, Stefaan; Vermeulen, An

Linking In Vitro Intrinsic Dissolution Rate and Thermodynamic Solubility with Pharmacokinetic Profiles of Bedaquiline Long-Acting Aqueous Microsuspensions in Rats.

Nguyen, Vy; Bevernage, Jan; Darville, Nicolas; Tistaert, Christophe; Van Bocxlaer, Jan; Rossenu, Stefaan; Vermeulen, An.

Afiliación

Nguyen V; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.
Bevernage J; Quantitative Sciences, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse B-2340, Belgium.
Darville N; Drug Product Development, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse B-2340, Belgium.
Tistaert C; Drug Product Development, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse B-2340, Belgium.
Van Bocxlaer J; Drug Product Development, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse B-2340, Belgium.
Rossenu S; Laboratory of Medical Biochemistry and Clinical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent B-9000, Belgium.
Vermeulen A; Quantitative Sciences, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse B-2340, Belgium.

Mol Pharm ; 18(3): 952-965, 2021 03 01.

Article en En | MEDLINE | ID: mdl-33400546

Asunto(s)

Diarilquinolinas/química; Diarilquinolinas/farmacocinética; Suspensiones/química; Suspensiones/farmacocinética; Agua/química; Animales; Química Farmacéutica/métodos; Excipientes/química; Excipientes/farmacocinética; Masculino; Poloxámero/química; Poloxámero/farmacocinética; Polietilenglicoles/química; Ratas; Ratas Sprague-Dawley; Solubilidad; Tensoactivos/química; Tensoactivos/farmacocinética; Termodinámica; Vitamina E/química; Vitamina E/farmacocinética

Palabras clave

aqueous microsuspensions; bedaquiline; intramuscular administration; intrinsic dissolution rate; long-acting injectables; pharmacokinetic profiles in rats; stabilizing excipient; subcutaneous administration; thermodynamic solubility

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Suspensiones / Agua / Diarilquinolinas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Pharm Asunto de la revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Estados Unidos

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