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Engineering microenvironment of biodegradable polyester systems for drug stability and release control.
Khaliq, Nisar Ul; Chobisa, Dhawal; Richard, Coralie A; Swinney, Monica R; Yeo, Yoon.
Afiliación
  • Khaliq NU; Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
  • Chobisa D; Department of Industrial & Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
  • Richard CA; Integrated Product Development Organization, Innovation Plaza, Dr.Reddy's Laboratories, Hyderabad 500090, India.
  • Swinney MR; Eli Lilly & Company,893 Delaware Street, Indianapolis, IN 46225, USA.
  • Yeo Y; Eli Lilly & Company, 450 Kendall Street, Cambridge, MA 02142, USA.
Ther Deliv ; 12(1): 37-54, 2021 01.
Article en En | MEDLINE | ID: mdl-33397135
Polymeric systems made of poly(lactic acid) or poly(lactic-co-glycolic acid) are widely used for long-term delivery of small and large molecules. The advantages of poly(lactic acid)/poly(lactic-co-glycolic acid) systems include biodegradability, safety and a long history of use in US FDA-approved products. However, as drugs delivered by the polymeric systems and their applications become more diverse, the significance of microenvironment change of degrading systems on long-term drug stability and release kinetics has gained renewed attention. In this review, we discuss various issues experienced with acidifying microenvironment of biodegradable polymer systems and approaches to overcome the detrimental effects of polymer degradation on drug stability and release control.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Ácido Láctico Idioma: En Revista: Ther Deliv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácido Poliglicólico / Ácido Láctico Idioma: En Revista: Ther Deliv Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido