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Efficacy of assisted reproductive technology after ovarian tissue transplantation in a cohort of 11 patients with or without associated infertility factors.
Vatel, M; Torre, A; Paillusson, B; Scheffler, F; Bergere, M; Benkhalifa, M; Le Martelot, M-T; Leperlier, F; Mirallié, S; Selleret, L; Prades-Borio, M; Neuraz, A; Barraud-Lange, V; Boissel, N; Fortin, A; Poirot, C.
Afiliación
  • Vatel M; Department of Reproductive Medicine, Clinique de la Muette, 75116, Paris, France.
  • Torre A; Division of Child Health, Department of Obstetrics and Gynaecology, University of Nottingham, Nottingham, UK.
  • Paillusson B; Department of Reproductive Medicine, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France.
  • Scheffler F; Department of Reproductive Medicine, Amiens Hospital, 80054, Amiens, France.
  • Bergere M; Department of Reproductive Biology, Poissy Saint-Germain-en-Laye Hospital, 78300, Poissy, France.
  • Benkhalifa M; Medicine and Reproductive Biology, University Hospital and School of Medicine, Picardy Jules Verne University, 80054, Amiens, France.
  • Le Martelot MT; Peritox-INERIS, UMR-I 01, Joint Research Centre, Picardy Jules Verne University, 80054, Amiens, France.
  • Leperlier F; Department of Reproductive Medicine, Brest Hospital, 29200, Brest, France.
  • Mirallié S; Department of Reproductive Medicine and Biology, Nantes Hospital, 44000, Nantes, France.
  • Selleret L; Department of Reproductive Medicine and Biology, Nantes Hospital, 44000, Nantes, France.
  • Prades-Borio M; Department of Gynecology and Obstetrics, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France.
  • Neuraz A; Department of Reproductive Biology, Assistance Publique des Hôpitaux de Paris (AP-HP), Tenon Hospital, 75020, Paris, France.
  • Barraud-Lange V; Department of Gynecology and Obstetrics, Les Bluets Hospital, 75012, Paris, France.
  • Boissel N; Department of Reproductive Biology, Assistance Publique-Hôpitaux de Paris (AP-HP), Cochin Hospital, 75014, Paris, France.
  • Fortin A; Department of Hematology, Adolescents and Young Adults Unit, Fertility Preservation, Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Louis Hospital, 1 Avenue Claude Vellefaux, 75010, Paris, France.
  • Poirot C; Paris University, EA3518, 75006, Paris, France.
J Assist Reprod Genet ; 38(2): 503-511, 2021 Feb.
Article en En | MEDLINE | ID: mdl-33389379
PURPOSE: IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor reproductive outcomes. The aim of this study was to evaluate the efficacy of ovarian tissue transplantation (OTT) followed by assisted reproductive technology (ART) in women with or without associated infertility factors. METHODS: This is a prospective cohort study with retrospective data collection including eleven women, four of whom having an infertility factor (IF), who had undergone OTT in one university center between 2005 and 2017, followed by ART in six in vitro fertilization (IVF) centers. RESULTS: In total, 25 of the 85 cycles initiated (29%) were canceled, resulting in 60 oocyte retrievals. Ninety-five oocytes were retrieved: 36 were abnormal or immature, 29/39 fertilized (74%) after ICSI and 13/20 (65%) after IVF. Thirty-five embryos were transferred in seven patients (5/7 patients without IF and 2/4 patients with IF). After ART, one patient with IF experienced two pregnancies, one resulting in a live birth. For all patients, pregnancy rates and live birth rates were 7.4% and 3.7% per embryo transfer, respectively. Nine pregnancies and four live births occurred after spontaneous conception in five patients without IF, none in the infertility group. CONCLUSION: This study confirms that IVF treatment in women with grafted frozen-thawed ovarian tissue is associated with poor outcomes. However, the chances of natural conception are high in women without IF. Patients with IF, without the possibility of spontaneous pregnancy, should be informed of poor reproductive outcomes after OTT followed by ART. TRIAL REGISTRATION NUMBER: NCT02184806.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Técnicas Reproductivas Asistidas / Folículo Ovárico / Infertilidad Femenina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Técnicas Reproductivas Asistidas / Folículo Ovárico / Infertilidad Femenina Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: J Assist Reprod Genet Asunto de la revista: GENETICA / MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos