Your browser doesn't support javascript.
loading
ß-endorphin at the intersection of pain and cancer progression: Preclinical evidence.
Argueta, Donovan A; Aich, Anupam; Lei, Jianxun; Kiven, Stacy; Nguyen, Aithanh; Wang, Ying; Gu, Joshua; Zhao, Weian; Gupta, Kalpna.
Afiliación
  • Argueta DA; Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
  • Aich A; Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
  • Lei J; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  • Kiven S; Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA.
  • Nguyen A; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
  • Wang Y; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Anesthesia, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Gu J; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, CA, USA.
  • Zhao W; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA; Department of Biological Chemistry, University of California, Irvine, CA, USA; Department of Pharmaceutical Sciences, Universit
  • Gupta K; Hematology/Oncology, Department of Medicine, University of California, Irvine, CA, USA; Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Southern California Institute for Research and Education, VA Medical Center, Long Beach
Neurosci Lett ; 744: 135601, 2021 01 23.
Article en En | MEDLINE | ID: mdl-33387660
We examined the association between endogenous opioid ß-endorphin, cancer progression and pain in a transgenic mouse model of breast cancer, with a rat C3(1) simian virus 40 large tumor antigen fusion gene (C3TAg). C3TAg mice develop ductal epithelial atypia at 8 weeks, progression to intra-epithelial neoplasia at 12 weeks, and invasive carcinoma with palpable tumors at 16 weeks. Consistent with invasive carcinoma at 4 months of age, C3TAg mice demonstrate a significant increase in hyperalgesia compared to younger C3TAg or control FVBN mice without tumors. Our data show that the growing tumor contributes to circulating ß-endorphin. As an endogenous ligand of mu opioid receptor, ß-endorphin has analgesic activity. Paradoxically, we observed an increase in pain in transgenic breast cancer mice with significantly high circulating and tumor-associated ß-endorphin. Increased circulating ß-endorphin correlates with increasing tumor burden. ß-endorphin induced the activation of mitogenic and survival-promoting signaling pathways, MAPK/ERK 1/2, STAT3 and Akt, observed by us in human MDA-MB-231 cells suggesting a role for ß-endorphin in breast cancer progression and associated pain.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Betaendorfina / Progresión de la Enfermedad / Dolor en Cáncer Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Neurosci Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Betaendorfina / Progresión de la Enfermedad / Dolor en Cáncer Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Neurosci Lett Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda