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Which blood cutoff value should be used for vitamin A deficiency in children aged 3-10 years? A systematic review.
Collese, Tatiana S; Norde, Marina M; Nascimento-Ferreira, Marcus V; Kim, Hanseul; Marchioni, Dirce M; Carvalho, Heráclito B; Giovannucci, Edward.
Afiliación
  • Collese TS; Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Department of Preventive Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Norde MM; Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.
  • Nascimento-Ferreira MV; Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Department of Preventive Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Kim H; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
  • Marchioni DM; Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil.
  • Carvalho HB; Youth/Child Cardiovascular Risk and Environmental (YCARE) Research Group, Department of Preventive Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Giovannucci E; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Nutr Rev ; 79(7): 777-787, 2021 06 04.
Article en En | MEDLINE | ID: mdl-33382883
CONTEXT: Blood cutoff values for vitamin A deficiency in children aged 3-10 years have not been addressed in the literature. OBJECTIVE: To identify blood retinol concentrations for determining severe vitamin A deficiency in children aged 3-10 years. DATA SOURCES: The MEDLINE, Web of Science, Embase, and Scopus databases were searched. DATA EXTRACTION: Two reviewers independently extracted article data and assessed quality. DATA ANALYSIS: The hierarchical summary receiver operating characteristic models were applied for the diagnostic accuracy meta-analysis. This review is registered at PROSPERO (identifier: CRD42020149367). RESULTS: A total of 15 articles met the eligibility criteria, and 9 were included in the diagnostic accuracy meta-analysis. The summary estimates (95%CI) were: Sensitivity, 0.39 (0.20-0.62); specificity, 0.79 (0.65-0.88); positive likelihood ratio, 1.85 (1.33-2.57); and negative likelihood ratio, 0.77 (0.60-0.99). The area under the curve of the overall analysis was 0.68 (95%CI 0.63-0.72). CONCLUSIONS: Blood retinol concentrations have low diagnostic accuracy for severe vitamin A deficiency in children aged 3-10 years. Therefore, there is unclear evidence about the preferable cutoff point for determining severe vitamin A deficiency in children in this age group.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina A / Deficiencia de Vitamina A Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Nutr Rev Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vitamina A / Deficiencia de Vitamina A Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Nutr Rev Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos