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Pulmonary hypertension in patients with sarcoidosis: A single-center experience.
Kaptan Özen, Deniz; Mutlu, Bülent; Kocakaya, Derya; Turan, Burak; Sert Sekerci, Sena; Ceyhan, Berrin.
Afiliación
  • Kaptan Özen D; Department of Cardiology, Derince Training and Research Hospital; Kocaeli-Turkey.
  • Mutlu B; Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; Istanbul-Turkey.
  • Kocakaya D; Department of Cardiology, Faculty of Medicine, Marmara University; Istanbul-Turkey.
  • Turan B; Department of Cardiology, Derince Training and Research Hospital; Kocaeli-Turkey.
  • Sert Sekerci S; Department of Pneomology, Faculty of Medicine, Marmara University; Istanbul-Turkey.
  • Ceyhan B; Department of Cardiology, Faculty of Medicine, Marmara University; Istanbul-Turkey.
Anatol J Cardiol ; 25(1): 36-41, 2021 01.
Article en En | MEDLINE | ID: mdl-33382054
OBJECTIVE: Sarcoidosis is a systemic granulomatous disease rarely complicated by pulmonary hypertension (PH). The prevalence of PH in sarcoidosis is unclear and has differences between ethnic groups. This study aimed to investigate the prevalence and predictors of PH in a Turkish cohort. METHODS: The study included 55 patients with biopsy-proven sarcoidosis in a single center. All patients underwent detailed transthoracic echocardiography (TTE) to assess the probability of PH as recommended. Right heart catheterization (RHC) was performed for patients with intermediate-high risk of PH. Patients with mean pulmonary artery pressure >20 mm Hg by RHC were defined as PH. Demographic and clinical characteristics, laboratory data, spirometry, 6-min walk test, and TTE were compared between low and intermediate-high risk PH groups. RESULTS: The probability of PH was low with 47 patients. Eight patients had intermediate-high probability of PH, and two of them refused to undergo RHC. Of six intermediate-high probability patients, three had PH, and all of them had post-precapillary PH. The prevalence of PH in sarcoidosis was 5.5% (3/55). Six-minute walk distance (6 MWD) and diastolic parameters (E/A ratio, E' wave, and left atrial volume) were significantly lower, and New York Heart association class and N-terminal probrain natriuretic peptide (NT-proBNP) level were higher in intermediate-high risk PH patients compared with low-risk PH patients. CONCLUSION: The frequency of PH in sarcoidosis was 5.5% in a Turkish cohort. NT-proBNP, 6 MWD, diastolic function parameters, and myocardial strain parameters can be useful predictors of PH in patients with sarcoidosis, besides known echocardiographic parameters.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Anatol J Cardiol Año: 2021 Tipo del documento: Article Pais de publicación: Turquía
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoidosis / Hipertensión Pulmonar Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Anatol J Cardiol Año: 2021 Tipo del documento: Article Pais de publicación: Turquía