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IL8, Neutrophils, and NETs in a Collusion against Cancer Immunity and Immunotherapy.
Teijeira, Alvaro; Garasa, Saray; Ochoa, Maria C; Villalba, Maria; Olivera, Irene; Cirella, Assunta; Eguren-Santamaria, Iñaki; Berraondo, Pedro; Schalper, Kurt A; de Andrea, Carlos E; Sanmamed, Miguel F; Melero, Ignacio.
Afiliación
  • Teijeira A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Navarra, Spain. imelero@unav.es ateijeiras@unav.es.
  • Garasa S; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
  • Ochoa MC; Navarra Institute for Health Research (IDISNA), Pamplona, Navarra, Spain.
  • Villalba M; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Navarra, Spain.
  • Olivera I; Navarra Institute for Health Research (IDISNA), Pamplona, Navarra, Spain.
  • Cirella A; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Navarra, Spain.
  • Eguren-Santamaria I; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
  • Berraondo P; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
  • Schalper KA; Department of Pathology, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
  • de Andrea CE; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Navarra, Spain.
  • Sanmamed MF; Navarra Institute for Health Research (IDISNA), Pamplona, Navarra, Spain.
  • Melero I; Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Navarra, Spain.
Clin Cancer Res ; 27(9): 2383-2393, 2021 05 01.
Article en En | MEDLINE | ID: mdl-33376096
One of the most important mechanisms by which cancer fosters its own development is the generation of an immune microenvironment that inhibits or impairs antitumor immune responses. A cancer permissive immune microenvironment is present in a large proportion of the patients with cancer who do not respond to immunotherapy approaches intended to trigger preexisting antitumor immune responses, for instance, immune checkpoint blockade. High circulating levels of IL8 in patients with cancer quite accurately predict those who will not benefit from checkpoint-based immunotherapy. IL8 has been reported to favor cancer progression and metastases via different mechanisms, including proangiogenesis and the maintenance of cancer stem cells, but its ability to attract and functionally modulate neutrophils and macrophages is arguably one of the most important factors. IL8 does not only recruit neutrophils to tumor lesions, but also triggers the extrusion of neutrophil extracellular traps (NET). The relevance and mechanisms underlying the contribution of both neutrophils and NETs to cancer development and progression are starting to be uncovered and include both direct effects on cancer cells and changes in the tumor microenvironment, such as facilitating metastasis, awakening micrometastases from dormancy, and facilitating escape from cytotoxic immune cells. Blockade of IL8 or its receptors (CXCR1 and CXCR2) is being pursued in drug development, and clinical trials alone or in combination with anti-PD-L1 checkpoint inhibitors are already ongoing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-8 / Microambiente Tumoral / Trampas Extracelulares / Neoplasias / Neutrófilos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-8 / Microambiente Tumoral / Trampas Extracelulares / Neoplasias / Neutrófilos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos