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Structural basis of γ-secretase inhibition and modulation by small molecule drugs.
Yang, Guanghui; Zhou, Rui; Guo, Xuefei; Yan, Chuangye; Lei, Jianlin; Shi, Yigong.
Afiliación
  • Yang G; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory for Agrobiotechnology, College of Biological Sciences, Chi
  • Zhou R; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Guo X; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Yan C; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Lei J; Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.
  • Shi Y; Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; Key Laboratory of Structural Biology of Zhejiang Province, School of Life Scien
Cell ; 184(2): 521-533.e14, 2021 01 21.
Article en En | MEDLINE | ID: mdl-33373587
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Inhibidores Enzimáticos / Secretasas de la Proteína Precursora del Amiloide / Bibliotecas de Moléculas Pequeñas Límite: Humans Idioma: En Revista: Cell Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos