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Gingival overgrowth induced by anticonvulsant drugs: A cross-sectional study on epileptic patients.
Gallo, Claudio; Bonvento, Giada; Zagotto, Giuseppe; Mucignat-Caretta, Carla.
Afiliación
  • Gallo C; Department of Neuroscience, University of Padova, Padova, Italy.
  • Bonvento G; 'Immacolata Concezione' Hospital, Piove di Sacco, Italy.
  • Zagotto G; Department of Neuroscience, University of Padova, Padova, Italy.
  • Mucignat-Caretta C; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
J Periodontal Res ; 56(2): 363-369, 2021 Apr.
Article en En | MEDLINE | ID: mdl-33368283
OBJECTIVE: Our aim was to estimate the prevalence of gingival overgrowth (hyperplasia) and to determine whether active molecules affect the severity of overgrowth in a group of epileptic patients. BACKGROUND: The effects of phenytoin on oral health have been explored in different studies, yet little information is available on other antiepileptic drugs. METHODS: Data were collected from 213 subjects of both sexes, from 5 to 80 years. Patients taking the same antiepileptic therapy for at least 1 year and meeting the inclusion criteria of the study (n = 162) were subjected to measurement of gingival overgrowth according to the modified Harris and Ewalt classification and O'Leary's plaque control record (OLR). Descriptive statistics were calculated. Data were analyzed using Pearson's r correlation coefficient and chi-square test. Significance level was set at 5%. RESULTS: The active drugs lamotrigine, oxcarbazepine, and phenobarbital were significantly associated with gingival overgrowth in 61%, 71%, and 53% of cases, respectively, and phenytoin, valproic acid, and carbamazepine in 50%, 44%, and 32% of cases, respectively. CONCLUSION: Different antiepileptic molecules may be related to gingival overgrowth. In addition to phenytoin, also lamotrigine, oxcarbazepine, and phenobarbital were associated with increased prevalence of gingival overgrowth. In the management of epileptic patients, dentists should take into account different drugs as possible causes for gingival overgrowth and warn for possible alternatives.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrecrecimiento Gingival / Epilepsia Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Periodontal Res Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sobrecrecimiento Gingival / Epilepsia Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Periodontal Res Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos