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CHRONIC MYELOID LEUKEMIA COURSE IN PERSONS EXPOSED TO IONIZING RADIATION AS A RESULT OF THE CHORNOBYL ACCIDENT. / PEREBIG KhRONIChNOÏ MIIeLOÏDNOÏ LEIKEMIÏ U OSIB, IaKI ZAZNALY DIÏ IONIZUIuChOGO VYPROMINIuVANNIa VNASLIDOK ChORNOBYL'S'KOÏ AVARIÏ.
Dyagil, I S; Dmytrenko, I V; Sholoiko, V V; Fedorenko, V G; Shlyakhtichenko, T Yu; Petrusha, O O; Martina, Z V; Tovstogan, A O; Silayev, Yu O; Stupakova, Z V; Minchenko, Z M.
Afiliación
  • Dyagil IS; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Dmytrenko IV; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Sholoiko VV; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Fedorenko VG; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Shlyakhtichenko TY; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Petrusha OO; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Martina ZV; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Tovstogan AO; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Silayev YO; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Stupakova ZV; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
  • Minchenko ZM; State Institution «National Research Center for radiation Medicine of the National Academy of medical Sciences of Ukraine¼, 53 Yury Illienko str., Kyiv, 04050, Ukraine.
Probl Radiac Med Radiobiol ; 25: 443-455, 2020 Dec.
Article en En, Uk | MEDLINE | ID: mdl-33361853
OBJECTIVE: Describe and characterize the peculiarities of the chronic myeloid leukemia (CML) course and responseto treatment in patients irradiated as a result of the Chornobyl nuclear power plant (ChNPP) accident based on theassessment of clinical-laboratory and clinical parameters. MATERIALS AND METHODS: The CML patients (n = 33) exposed to ionizing radiation as a result of the ChNPP accidentwere enrolled. The comparison group consisted of CML patients (n = 725) with no history of radiation exposure. Allpatients were in the chronic phase of the disease. Clinical, hematological and molecular genetic research methodswere applied. RESULTS: Patients exposed to ionizing radiation as a result of the ChNPP accident had no differences in CML manifestation, as well as in classical genetic markers at the onset of the disease compared with patients with no historyof radiation exposure. Reduction of tumor clone on imatinib therapy was significantly less effective in the patientsexposed to ionizing radiation than in cases of no history of radiation exposure. Cases of primary resistance were statistically significantly prevalent in the ChNPP accident consequences clean-up workers while in the residents ofradiologically contaminated areas a statistically significant increase in probability of loss of complete cytogeneticresponse (development of secondary resistance) to imatinib therapy was found. An association was found betweenthe radiation exposure and probability of loss of complete cytogenetic response to imatinib therapy in this group ofpatients. CONCLUSION: The radiation exposure in the history even many years before the onset of CML is an unfavorable exogenous factor responsible for the development of resistance to imatinib therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Leucemia Mielógena Crónica BCR-ABL Positiva / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas de Fusión bcr-abl / Exposición a la Radiación / Accidente Nuclear de Chernóbil Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En / Uk Revista: Probl Radiac Med Radiobiol Año: 2020 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Ucrania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos por Radiación / Leucemia Mielógena Crónica BCR-ABL Positiva / Protocolos de Quimioterapia Combinada Antineoplásica / Proteínas de Fusión bcr-abl / Exposición a la Radiación / Accidente Nuclear de Chernóbil Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En / Uk Revista: Probl Radiac Med Radiobiol Año: 2020 Tipo del documento: Article País de afiliación: Ucrania Pais de publicación: Ucrania