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Luteolin attenuates angiotensin II­induced renal damage in apolipoprotein E­deficient mice.
Liu, Ying-Shu; Yang, Qin; Li, Shen; Luo, Lan; Liu, Hong-Yang; Li, Xin-Yu; Gao, Zheng-Nan.
Afiliación
  • Liu YS; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
  • Yang Q; Department of Internal Medicine, The Affiliated Zhong Shan Hospital of Dalian University, Dalian, Liaodong 116011, P.R. China.
  • Li S; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
  • Luo L; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
  • Liu HY; Department of Heart Intensive Care Unit, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
  • Li XY; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
  • Gao ZN; Department of Endocrinology, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, Liaodong 116011, P.R. China.
Mol Med Rep ; 23(2)2021 02.
Article en En | MEDLINE | ID: mdl-33355379
Renal damage is a common and severe condition encountered in the clinic. Luteolin (Lut) exhibits anti­inflammatory, anti­fibrotic and anti­apoptotic effects. Thus, the present study aimed to investigate the pharmacological effects of Lut on angiotensin II (AngII)­induced renal damage in apolipoprotein E­deficient (ApoE­/­) mice. Male ApoE­/­ mice (age, 8 weeks) were randomly divided into the following three groups: i) Control group (n=6); ii) AngII group (n=6); and iii) AngII + Lut group (n=6). Lut was administered by gavage (100 mg/kg/d). ApoE­/­ mice were implanted with Alzet osmotic minipumps, filled with either saline vehicle or AngII solution for a maximum period of 4 weeks. After 4 weeks, metabolic characteristics were measured and the histopathological alterations in the kidney tissue were observed. The metabolic characteristics of blood creatinine (CRE) levels were lower in the AngII + Lut group compared with in the AngII group. The expression levels of collagen I and III were lower in the kidney tissues of the AngII + Lut group compared with the corresponding tissues of the AngII group. The gene expression levels of IL­1ß, IL­6, TNF­α and IL­10 were also suppressed in the kidney tissues of the AngII + Lut group compared with those in the corresponding tissues of the AngII group. Furthermore, the AngII + Lut group exhibited markedly increased LC3 protein expression and notably decreased p62 protein expression in the kidney tissues compared with the expression levels in the AngII group. The data demonstrated that Lut attenuated AngII­induced collagen deposition and inflammation, while inducing autophagy. Collectively, the results suggested that Lut treatment exhibited a exerted effect on AngII­induced renal injury in ApoE­/­ mice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiotensina II / Luteolina / Riñón / Enfermedades Renales Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2021 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Angiotensina II / Luteolina / Riñón / Enfermedades Renales Límite: Animals Idioma: En Revista: Mol Med Rep Año: 2021 Tipo del documento: Article Pais de publicación: Grecia