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[Status of content analysis of pyrrolizidine alkaloids in food and herbs].
Yan, Zhang; Si-Qi, M A; Fei-Fei, Yang; Jian-Yong, S I; Qing, W U; Yong-Hong, Liao.
Afiliación
  • Yan Z; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100102, China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Si-Qi MA; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Fei-Fei Y; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Jian-Yong SI; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
  • Qing WU; School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 100102, China.
  • Yong-Hong L; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193, China.
Zhongguo Zhong Yao Za Zhi ; 45(22): 5421-5428, 2020 Nov.
Article en Zh | MEDLINE | ID: mdl-33350201
Pyrrolizidine alkaloids(PAs) are a group of naturally occurring alkaloids with a pyrrolizidine skeleton which can be found in about 3% of the world's flowering plants. It is notorious that PAs are cause the hepatoxic and genotoxic-carcinogenic effects by taking PA-containing herbs, food and dietary supplements. In order to control the poisoning caused by PAs, European Medicines Agency has set a limit of intake of PAs from herbal medicinal products at 0.007 µg of 1,2-unsaturated PAs/kg body weight. Nonetheless, a systematic overview of the amount of PAs in the herb has not been provided. Therefore, this paper is to systematically review the current status of PAs content analysis of herbal medicines and foods reported in the literature, and to provide theoretical and experimental support for the safety risk assessment and control of PAs in Chinese herbal medicines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Alcaloides de Pirrolicidina Tipo de estudio: Risk_factors_studies / Systematic_reviews Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plantas Medicinales / Alcaloides de Pirrolicidina Tipo de estudio: Risk_factors_studies / Systematic_reviews Idioma: Zh Revista: Zhongguo Zhong Yao Za Zhi Asunto de la revista: FARMACOLOGIA / TERAPIAS COMPLEMENTARES Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: China