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Serum cytokines in astrocytic brain tumors: a prospective study.
Ansari, Tariq; Dutta, Gautam; Srivastava, Arvind Kumar; Jagetia, Anita; Singh, Daljit; Singh, Hukum; Bharti, Rohit; Prakash, Anand; Kumar, Anil.
Afiliación
  • Ansari T; Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
  • Dutta G; Department of Neuro-Surgery, Rajendra Institute of Medical Sciences (RIMS), Jharkhand, India.
  • Srivastava AK; Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
  • Jagetia A; Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
  • Singh D; Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
  • Singh H; Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
  • Bharti R; Department of Neuro-Surgery, Rajendra Institute of Medical Sciences (RIMS), Jharkhand, India.
  • Prakash A; Department of Neuro-Surgery, Rajendra Institute of Medical Sciences (RIMS), Jharkhand, India.
  • Kumar A; Department of Neuro-Surgery, Rajendra Institute of Medical Sciences (RIMS), Jharkhand, India.
Br J Neurosurg ; 37(1): 35-40, 2023 Feb.
Article en En | MEDLINE | ID: mdl-33349075
BACKGROUND: Gliomas are the most aggressive form of brain tumors responsible for the majority of brain cancer related deaths. Interleukin (IL)-6, 10 and tumor necrosis factor (TNF)- α are tumor specific proteins that are expressed in gliomas. This study aims to estimate the pre- and postoperative levels of serum markers of these cytokines to evaluate any bearing with its grade and volume. METHODS: Prospective analysis of 80 patients of newly-diagnosed gliomas of any grade was carried out. Pre- and postoperative blood samples day one, one month and at 3rd month of surgery was taken and levels of IL-6, 10 and TNF- α measured and matched with 20 healthy controls. RESULTS: Of the 80 patients, 3 patients had pilocytic astrocytoma, 4 had ganglioglioma, 9 had oligodendroglioma, 17 had diffuse astrocytoma, 5 had anaplastic astrocytoma while 43 had glioblastoma. Preoperative levels of IL-6 and TNF- α was found to be markedly raised in high grade gliomas. Positive correlation was seen between IL-6 with the grade of tumor and high-grade tumors were seen to be more significantly correlated with IL-6. However, preoperative IL-10 in both low and high grade of gliomas did not show any correlation with the volume and grade of tumor. CONCLUSION: High level of IL-6 and TNF-α in peripheral blood in patients of high-grade gliomas provides clue to the invasiveness of the disease which can be useful for understanding the premorbid development of tumor and perhaps extrapolating to ongoing tumor response to treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Glioma Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Br J Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Astrocitoma / Neoplasias Encefálicas / Glioma Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Br J Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2023 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido