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Effects of continuous positive airway pressure on resolvin and matrix metalloproteinase-9 in patients with obstructive sleep apnea.
Lin, Ching-Chi; Chen, Wei-Ji; Sun, Yi-Kun; Chiu, Chung-Hsin; Lin, Mei-Wei; Tzeng, I-Shiang.
Afiliación
  • Lin CC; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. Electronic address: cclinpro@yahoo.com.
  • Chen WJ; Division of Pulmonary Medicine, Department of Internal Medicine, Lukang Christian Hospital, Changhua, Taiwan.
  • Sun YK; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
  • Chiu CH; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
  • Lin MW; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
  • Tzeng IS; Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Respir Physiol Neurobiol ; 285: 103603, 2021 03.
Article en En | MEDLINE | ID: mdl-33348057
PURPOSE: Resolvin is a checkpoint controller in inflammation. Matrix metalloproteinase-9 (MMP-9) is an airway remodeling regulator. We evaluated the levels of resolvin and MMP-9 protein in the serum and exhaled breath condensate (EBC) before and after continuous positive airway pressure (CPAP) treatment. METHOD: We enrolled 20 non-OSA snorers and 40 patients with moderate to severe OSA scheduled for CPAP treatment. ELISA was used to assess resolvin and MMP-9 levels in the serum and EBC. All patients underwent sleep assessment at baseline and 3 months after CPAP. RESULTS: There was no between-group difference; moreover, there were no differences in the pre- and post-treatment serum levels of resolvin and MMP-9 in patients with OSA. Compared with non-OSA snorers, patients with OSA had lower resolvin and higher MMP-9 levels in the EBC. After CPAP treatment, the EBC levels of resolvin and MMP-9 in patients with OSA returned to normal. CONCLUSIONS: Successful OSA treatment by CPAP can normalize EBC levels of resolvin and MMP-9.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ronquido / Ácidos Docosahexaenoicos / Mediadores de Inflamación / Apnea Obstructiva del Sueño / Metaloproteinasa 9 de la Matriz / Presión de las Vías Aéreas Positiva Contínua Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Physiol Neurobiol Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ronquido / Ácidos Docosahexaenoicos / Mediadores de Inflamación / Apnea Obstructiva del Sueño / Metaloproteinasa 9 de la Matriz / Presión de las Vías Aéreas Positiva Contínua Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Physiol Neurobiol Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos