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The impact of physical frailty on the response to inactivated influenza vaccine in older adults.
Moehling, Krissy K; Zhai, Bo; Schwarzmann, William E; Chandran, Uma R; Ortiz, Marianna; Nowalk, Mary Patricia; Nace, David; Lin, Chyongchiou J; Susick, Michael; Levine, Min Z; Alcorn, John F; Zimmerman, Richard K.
Afiliación
  • Moehling KK; Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Zhai B; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA.
  • Schwarzmann WE; Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  • Chandran UR; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Ortiz M; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Nowalk MP; Division of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  • Nace D; Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Lin CJ; Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  • Susick M; Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Levine MZ; Ohio State University College of Nursing, Columbus, OH 43210, USA.
  • Alcorn JF; Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Zimmerman RK; National Center for Immunization and Respiratory Diseases, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.
Aging (Albany NY) ; 12(24): 24633-24650, 2020 12 09.
Article en En | MEDLINE | ID: mdl-33347425
Physical frailty's impact on hemagglutination inhibition antibody titers (HAI) and peripheral blood mononuclear cell (PBMC) transcriptional responses after influenza vaccination is unclear. Physical frailty was assessed using the 5-item Fried frailty phenotype in 168 community- and assisted-living adults ≥55 years of age during an observational study. Blood was drawn before, 3, 7, and 28 days post-vaccination with the 2017-2018 inactivated influenza vaccine. HAI response to the A/H1N1 strain was measured at Days 0 and 28 using seropositivity, seroconversion, log2 HAI titers, and fold-rise in log2 HAI titers. RNA sequencing of PBMCs from Days 0, 3 and 7 was measured in 28 participants and compared using pathway analyses. Frailty was not significantly associated with any HAI outcome in multivariable models. Compared with non-frail participants, frail participants expressed decreased cell proliferation, metabolism, antibody production, and interferon signaling genes. Conversely, frail participants showed elevated gene expression in IL-8 signaling, T-cell exhaustion, and oxidative stress pathways compared with non-frail participants. These results suggest that reduced effectiveness of influenza vaccine among older, frail individuals may be attributed to immunosenescence-related changes in PBMCs that are not reflected in antibody levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Vacunas de Productos Inactivados / Proliferación Celular / Gripe Humana / Fragilidad / Formación de Anticuerpos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas contra la Influenza / Vacunas de Productos Inactivados / Proliferación Celular / Gripe Humana / Fragilidad / Formación de Anticuerpos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Aging (Albany NY) Asunto de la revista: GERIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos