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Biological Cells as Therapeutic Delivery Vehicles.
Bush, Lucas M; Healy, Connor P; Javdan, Shwan B; Emmons, Jonathan C; Deans, Tara L.
Afiliación
  • Bush LM; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
  • Healy CP; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
  • Javdan SB; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
  • Emmons JC; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA.
  • Deans TL; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: tara.deans@utah.edu.
Trends Pharmacol Sci ; 42(2): 106-118, 2021 02.
Article en En | MEDLINE | ID: mdl-33342562
One of the significant challenges remaining in the field of drug delivery is insufficient targeting of diseased tissues or cells. While efforts to perform targeted drug delivery by engineered nanoparticles have shown some success, there are underlying targeting, toxicity, and immunogenicity challenges. By contrast, live cells usually have innate targeting mechanisms, and can be used as drug-delivery vehicles to increase the efficiency with which a drug accumulates to act on the intended tissue. In some cases, when no native cell types exhibit the desired therapeutic phenotype, preferred outcomes can be achieved by genetically modifying and reprogramming cells with gene circuits. This review highlights recent advances in the use of cells to deliver therapeutics. Specifically, we discuss how red blood cells (RBCs), platelets, neutrophils, mesenchymal stem cells (MSCs), and bacteria have been utilized to advance drug delivery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Idioma: En Revista: Trends Pharmacol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Trasplante de Células Madre Mesenquimatosas / Células Madre Mesenquimatosas Idioma: En Revista: Trends Pharmacol Sci Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido