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Nephroprotection through Modifying the Apoptotic TNF-α/ERK1/2/Bax Signaling Pathway and Oxidative Stress by Long-term Sodium Hydrosulfide Administration in Ovalbumin-induced Chronic Asthma.
Kianian, Farzaneh; Seifi, Behjat; Kadkhodaee, Mehri; Sadeghipour, Hamid Reza; Ranjbaran, Mina.
Afiliación
  • Kianian F; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Seifi B; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Kadkhodaee M; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Sadeghipour HR; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Ranjbaran M; Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Immunol Invest ; 51(3): 602-618, 2022 Apr.
Article en En | MEDLINE | ID: mdl-33342312
Asthma is one of the most common respiratory diseases in the world. Nevertheless, it is reported that inflammation induced by asthma is not only restricted to the lung and may cause damaging effects on remote organs. Therefore, this study was designed to investigate the beneficial effects of long-term sodium hydrosulfide (NaHS) administration on lung inflammation and oxidative stress markers to protect the kidney during chronic asthma. BALB/c mice were divided into three groups (n = 5-7): control, asthma and NaHS. Except the control group, sensitization and challenge were performed with ovalbumin. The NaHS group intraperitoneally received 14 µmol/kg NaHS 30 min before each challenge. 24 h after the last challenge, samples of bronchoalveolar lavage fluid (BALF), plasma, lung and kidney tissues were collected. NaHS administration significantly decreased total white blood cell count, percentages of eosinophils, neutrophils and macrophages and increased percentage of lymphocytes. Administration of NaHS considerably decreased the levels of BALF interleukin-13, plasma tumor necrosis factor-alpha (TNF-α), lung malondialdehyde (MDA) and lung phosphorylated nuclear factor-kappa B (p-NF-κB) expression and scores of peribronchial inflammatory cell infiltration, goblet cell hyperplasia and subepithelial fibrosis and increased the activity of lung superoxide dismutase (SOD). The MDA levels and expressions of p-ERK1/2 and Bax were decreased and SOD activity and expressions of Bcl-2 and p-Akt were significantly increased in kidney tissues by NaHS administration. Administration of NaHS decreased renal oxidative stress indices and reduced apoptosis by the inhibition of TNF-α/ERK1/2/Bax. Therefore, H2S may have an essential role in renal protection during asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Factor de Necrosis Tumoral alfa Límite: Animals Idioma: En Revista: Immunol Invest Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Factor de Necrosis Tumoral alfa Límite: Animals Idioma: En Revista: Immunol Invest Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Reino Unido