Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.

Takagi, Tomohisa; Naito, Yuji; Higashimura, Yasuki; Uchiyama, Kazuhiko; Okayama, Tetsuya; Mizushima, Katsura; Katada, Kazuhiro; Kamada, Kazuhiro; Ishikawa, Takeshi; Itoh, Yoshito

Takagi, Tomohisa; Naito, Yuji; Higashimura, Yasuki; Uchiyama, Kazuhiko; Okayama, Tetsuya; Mizushima, Katsura; Katada, Kazuhiro; Kamada, Kazuhiro; Ishikawa, Takeshi; Itoh, Yoshito.

Afiliación

Takagi T; Department for Medical Innovation and Translational Medical Science, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 6
Naito Y; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Higashimura Y; Department of Food Science, Ishikawa Prefectural University, Nonoichi, 921-8836, Japan.
Uchiyama K; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Okayama T; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Mizushima K; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Katada K; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Kamada K; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Ishikawa T; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.
Itoh Y; Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602-8566, Japan.

Nitric Oxide ; 107: 19-30, 2021 02 01.

Article en En | MEDLINE | ID: mdl-33340673

Asunto(s)

Monóxido de Carbono/uso terapéutico; Colitis/prevención & control; Inflamación/prevención & control; Transducción de Señal/efectos de los fármacos; Cicatrización de Heridas/efectos de los fármacos; Quinasas Asociadas a rho/metabolismo; Administración Rectal; Animales; Monóxido de Carbono/administración & dosificación; Células Cultivadas; Quimiocina CXCL1/metabolismo; Colitis/inducido químicamente; Colon/efectos de los fármacos; Colon/patología; Inflamación/inducido químicamente; Mucosa Intestinal/efectos de los fármacos; Masculino; Peroxidasa/metabolismo; ARN Mensajero/metabolismo; Ratas Wistar; Repitelización/efectos de los fármacos; Ácido Trinitrobencenosulfónico

Palabras clave

Carbon monoxide; Rho kinase; TNBS-Induced colitis; Wound healing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Monóxido de Carbono / Transducción de Señal / Colitis / Quinasas Asociadas a rho / Inflamación Límite: Animals Idioma: En Revista: Nitric Oxide Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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