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The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.
Queissner, R; Lenger, M; Birner, A; Dalkner, N; Fellendorf, F; Bengesser, S; Platzer, M; Hamm, C; Maget, A; Reininghaus, B; Ratzenhofer, M; Schuller, J; Mangge, H; Kapfhammer, H P; Reininghaus, E Z.
Afiliación
  • Queissner R; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Lenger M; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Birner A; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria. Electronic address: armin.birner@medunigraz.at.
  • Dalkner N; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Fellendorf F; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Bengesser S; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Platzer M; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Hamm C; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Maget A; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Reininghaus B; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Ratzenhofer M; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Schuller J; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Mangge H; Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.
  • Kapfhammer HP; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
  • Reininghaus EZ; Medical University of Graz, Department of Psychiatry and Psychotherapeutic Medicine, Graz, Austria.
J Affect Disord ; 281: 228-234, 2021 02 15.
Article en En | MEDLINE | ID: mdl-33338840
INTRODUCTION: Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-term lithium treatment, chronic inflammatory processes and symptom progression. Furthermore, the association between duration of lithium treatment and levels of hsCRP was explored. METHODS: 267 individuals (males= 139, females= 128) with BD were included. Duration of lithium treatment as well as symptom progression, defined as the increase in severity of symptoms, number of episodes a year and duration of episodes within a period of 1.5 years in the past and hsCRP were evaluated. RESULTS: Male individuals with symptom progression over time had significantly lower duration of lithium treatment compared to individuals without symptoms progression (U= 47.4, p=.037). There were significantly higher levels of hsCRP in male individuals with symptom progression compared to males without symptom progression (U= 47.5, p=.027). Further, there was a significant negative correlation between the duration of lithium treatment and hsCRP levels in the whole sample (r= -.276, p<.05). CONCLUSION: Our results show that an altered inflammatory state may be associated with a more severe illness course in BD. Further, a longer duration of lithium treatment may be associated with lower symptom progression. The shown association between hsCRP-levels and lithium treatment duration suggests a potential anti-inflammatory effect of lithium as a mediator of its significant positive outcome effect in BD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Litio Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Bipolar / Litio Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Affect Disord Año: 2021 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Países Bajos