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Platelet cloaking of circulating tumour cells in patients with metastatic prostate cancer: Results from ExPeCT, a randomised controlled trial.
Brady, Lauren; Hayes, Brian; Sheill, Gráinne; Baird, Anne-Marie; Guinan, Emer; Stanfill, Bryan; Vlajnic, Tatjana; Casey, Orla; Murphy, Verena; Greene, John; Allott, Emma H; Hussey, Juliette; Cahill, Fidelma; Van Hemelrijck, Mieke; Peat, Nicola; Mucci, Lorelei; Cunningham, Moya; Grogan, Liam; Lynch, Thomas; Manecksha, Rustom P; McCaffrey, John; O'Donnell, Dearbhaile; Sheils, Orla; O'Leary, John; Rudman, Sarah; McDermott, Ray; Finn, Stephen.
Afiliación
  • Brady L; Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Hayes B; Department of Histopathology, Cork University Hospital, Cork, Ireland.
  • Sheill G; Department of Pathology, University College Cork, Cork, Ireland.
  • Baird AM; Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Guinan E; Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Stanfill B; School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Vlajnic T; Pacific Northwest National Laboratory, Richland, Washington, United States of America.
  • Casey O; Institute of Pathology, University Hospital Basel, Basel, Switzerland.
  • Murphy V; Cancer Trials Ireland, Dublin, Ireland.
  • Greene J; Cancer Trials Ireland, Dublin, Ireland.
  • Allott EH; Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Hussey J; Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Cahill F; Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.
  • Van Hemelrijck M; Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Peat N; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology (TOUR), London, United Kingdom.
  • Mucci L; King's College London, School of Cancer and Pharmaceutical Sciences, Translational Oncology and Urology (TOUR), London, United Kingdom.
  • Cunningham M; Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
  • Grogan L; Harvard T.H. Chan school of Public Health, Boston, Massachusetts, United States of America.
  • Lynch T; Department of Radiation Oncology, St Luke's Hospital, Dublin, Ireland.
  • Manecksha RP; Department of Oncology, Beaumont Hospital, Dublin, Ireland.
  • McCaffrey J; Department of Urology, St James's Hospital, Dublin, Ireland.
  • O'Donnell D; Department of Urology, St James's Hospital, Dublin, Ireland.
  • Sheils O; Department of Surgery, Trinity College Dublin, Dublin, Ireland.
  • O'Leary J; Department of Oncology, Mater Misericordiae Hospital, Dublin, Ireland.
  • Rudman S; HOPE Directorate, St James's Hospital, Dublin, Ireland.
  • McDermott R; Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
  • Finn S; Department of Histopathology, St James's Hospital, Dublin, Ireland.
PLoS One ; 15(12): e0243928, 2020.
Article en En | MEDLINE | ID: mdl-33338056
BACKGROUND: Circulating tumour cells (CTCs) represent a morphologically distinct subset of cancer cells, which aid the metastatic spread. The ExPeCT trial aimed to examine the effectiveness of a structured exercise programme in modulating levels of CTCs and platelet cloaking in patients with metastatic prostate cancer. METHODS: Participants (n = 61) were randomised into either standard care (control) or exercise arms. Whole blood was collected for all participants at baseline (T0), three months (T3) and six months (T6), and analysed for the presence of CTCs, CTC clusters and platelet cloaking. CTC data was correlated with clinico-pathological information. RESULTS: Changes in CTC number were observed within group over time, however no significant difference in CTC number was observed between groups over time. Platelet cloaking was identified in 29.5% of participants. A positive correlation between CTC number and white cell count (WCC) was observed (p = 0.0001), in addition to a positive relationship between CTC clusters and PSA levels (p = 0.0393). CONCLUSION: The presence of platelet cloaking has been observed in this patient population for the first time, in addition to a significant correlation between CTC number and WCC. TRIAL REGISTRATION: ClincalTrials.gov identifier NCT02453139.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Plaquetas / Biomarcadores de Tumor / Células Neoplásicas Circulantes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Plaquetas / Biomarcadores de Tumor / Células Neoplásicas Circulantes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Estados Unidos