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Fine Customization of Calcium Phosphate Nanostructures with Site-Specific Modification by DNA Templated Mineralization.
Wu, Shanshan; Zhang, Meizhou; Song, Jie; Weber, Stefan; Liu, Xiaoguo; Fan, Chunhai; Wu, Yuzhou.
Afiliación
  • Wu S; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Load, Wuhan 430074, China.
  • Zhang M; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Load, Wuhan 430074, China.
  • Song J; Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
  • Weber S; Max Planck Institute for Polymer Research, Ackermannweg 10, Mainz 55128, Germany.
  • Liu X; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200024, China.
  • Fan C; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200024, China.
  • Wu Y; Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Load, Wuhan 430074, China.
ACS Nano ; 15(1): 1555-1565, 2021 01 26.
Article en En | MEDLINE | ID: mdl-33332975
Calcium phosphate (Ca-P) is the most abundant biomineral in hard tissues with diverse microstructures, which in nature ensure a broad range of functionalities with virtually similar and simple chemical compositions. Artificial fabrication of rationally designed Ca-P materials with arbitrary microstructures is a long-standing challenge for inorganic chemists. Although DNA nanotechnology has been elegantly used to modulate the nanofabrication of inorganic materials because of its programmability, encoding customized Ca-P mineralization with high structural precision remains unachievable because of fast affinity-driven crystal growth. Herein, this long-standing ambition has been skillfully fulfilled by taking advantage of crystallization via a particle attachment (CPA) process. The derived hybrid materials not only well inherited the structural details encoded by the DNA template but also exhibited significantly enhanced mechanical strength, even after heating. Moreover, this method preserved preinstalled synthetic functionalities on the DNA surface, allowing for downstream site-specific modification.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras Idioma: En Revista: ACS Nano Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanoestructuras Idioma: En Revista: ACS Nano Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos