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Transcriptome Reprogramming of CD11b+ Bone Marrow Cells by Pancreatic Cancer Extracellular Vesicles.
Maia, Joana; Otake, Andreia Hanada; Poças, Juliana; Carvalho, Ana Sofia; Beck, Hans Christian; Magalhães, Ana; Matthiesen, Rune; Strano Moraes, Maria Carolina; Costa-Silva, Bruno.
Afiliación
  • Maia J; Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, Portugal.
  • Otake AH; Graduate Program in Areas of Basic and Applied Biology, University of Porto, Porto, Portugal.
  • Poças J; Champalimaud Centre for the Unknown, Champalimaud Foundation, Lisbon, Portugal.
  • Carvalho AS; Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Beck HC; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  • Magalhães A; IPATIMUP - Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal.
  • Matthiesen R; Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
  • Strano Moraes MC; Computational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
  • Costa-Silva B; Centre for Clinical Proteomics, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.
Front Cell Dev Biol ; 8: 592518, 2020.
Article en En | MEDLINE | ID: mdl-33330473
Pancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM cells and induce the expansion of this cell population. Transcriptomic characterization of these cells shows that PC-EVs upregulate IgG and IgA genes, which have been linked to the presence of monocytes/macrophages in tumor microenvironments. We also report here the transcriptional downregulation of genes linked to monocyte/macrophage activation, trafficking, and expression of inflammatory molecules. Together, these results show for the first time the existence of a PC-BM communication axis mediated by EVs with a potential role in PC tumor microenvironments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Suiza