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MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs.
Alwin Prem Anand, A; Alvarez-Bolado, Gonzalo; Wizenmann, Andrea.
Afiliación
  • Alwin Prem Anand A; Institute of Clinical Anatomy and Cell Analysis, University of Tuebingen, Tuebingen, Germany.
  • Alvarez-Bolado G; Department of Neuroanatomy, University of Heidelberg, Heidelberg, Germany.
  • Wizenmann A; Institute of Clinical Anatomy and Cell Analysis, University of Tuebingen, Tuebingen, Germany.
Front Cell Dev Biol ; 8: 586158, 2020.
Article en En | MEDLINE | ID: mdl-33330463
MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza