Robust p53 Stabilization Is Dispensable for Its Activation and Tumor Suppressor Function.

Kon, Ning; Churchill, Michael; Li, Huan; Mukherjee, Siddhartha; Manfredi, James J; Gu, Wei

Kon, Ning; Churchill, Michael; Li, Huan; Mukherjee, Siddhartha; Manfredi, James J; Gu, Wei.

Afiliación

Kon N; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Churchill M; Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Li H; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Mukherjee S; Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York.
Manfredi JJ; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Gu W; Institute for Cancer Genetics, Department of Pathology and Cell Biology, and Herbert Irving Comprehensive Cancer Center, College of Physicians & Surgeons, Columbia University, New York, New York. wg8@cumc.columbia.edu.

Cancer Res ; 81(4): 935-944, 2021 02 15.

Article en En | MEDLINE | ID: mdl-33323382

Asunto(s)

Proteína p53 Supresora de Tumor/metabolismo; Proteína p53 Supresora de Tumor/fisiología; Acetilación; Animales; Apoptosis/genética; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/metabolismo; Carcinoma Ductal Pancreático/patología; Células Cultivadas; Daño del ADN/genética; Genes Supresores de Tumor/fisiología; Lisina/metabolismo; Ratones; Ratones Transgénicos; Proteínas Mutantes/genética; Proteínas Mutantes/metabolismo; Proteínas Mutantes/fisiología; Mutación; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Neoplasias Pancreáticas/patología; Procesamiento Proteico-Postraduccional/genética; Estabilidad Proteica; Activación Transcripcional/genética; Proteína p53 Supresora de Tumor/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína p53 Supresora de Tumor Límite: Animals Idioma: En Revista: Cancer Res Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos

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