Your browser doesn't support javascript.
loading
Altered metabolism of mothers of young children with Autism Spectrum Disorder: a case control study.
Hollowood-Jones, Kathryn; Adams, James B; Coleman, Devon M; Ramamoorthy, Sivapriya; Melnyk, Stepan; James, S Jill; Woodruff, Bryan K; Pollard, Elena L; Snozek, Christine L; Kruger, Uwe; Chuah, Joshua; Hahn, Juergen.
Afiliación
  • Hollowood-Jones K; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th St, Troy, NY, 12180, USA.
  • Adams JB; School for Engineering of Matter, Transport and Energy, Arizona State University, P.O. Box 879309, ECG 302, 501 E Tyler Mall, Tempe, AZ, 85287-9309, USA. Jim.Adams@asu.edu.
  • Coleman DM; School for Engineering of Matter, Transport and Energy, Arizona State University, P.O. Box 879309, ECG 302, 501 E Tyler Mall, Tempe, AZ, 85287-9309, USA.
  • Ramamoorthy S; Metabolon, 617 Davis Drive, Suite 100, Morrisville, NC, 27560, USA.
  • Melnyk S; University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA.
  • James SJ; University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA.
  • Woodruff BK; Mayo Clinic, 13400 E. Sea Blvd, Scottsdale, AZ, 85259, USA.
  • Pollard EL; School for Engineering of Matter, Transport and Energy, Arizona State University, P.O. Box 879309, ECG 302, 501 E Tyler Mall, Tempe, AZ, 85287-9309, USA.
  • Snozek CL; Mayo Clinic, 13400 E. Sea Blvd, Scottsdale, AZ, 85259, USA.
  • Kruger U; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th St, Troy, NY, 12180, USA.
  • Chuah J; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th St, Troy, NY, 12180, USA.
  • Hahn J; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th St, Troy, NY, 12180, USA. hahnj@rpi.edu.
BMC Pediatr ; 20(1): 557, 2020 12 14.
Article en En | MEDLINE | ID: mdl-33317469
BACKGROUND: Previous research studies have demonstrated abnormalities in the metabolism of mothers of young children with autism. METHODS: Metabolic analysis was performed on blood samples from 30 mothers of young children with Autism Spectrum Disorder (ASD-M) and from 29 mothers of young typically-developing children (TD-M). Targeted metabolic analysis focusing on the folate one-carbon metabolism (FOCM) and the transsulfuration pathway (TS) as well as broad metabolic analysis were performed. Statistical analysis of the data involved both univariate and multivariate statistical methods. RESULTS: Univariate analysis revealed significant differences in 5 metabolites from the folate one-carbon metabolism and the transsulfuration pathway and differences in an additional 48 metabolites identified by broad metabolic analysis, including lower levels of many carnitine-conjugated molecules. Multivariate analysis with leave-one-out cross-validation allowed classification of samples as belonging to one of the two groups of mothers with 93% sensitivity and 97% specificity with five metabolites. Furthermore, each of these five metabolites correlated with 8-15 other metabolites indicating that there are five clusters of correlated metabolites. In fact, all but 5 of the 50 metabolites with the highest area under the receiver operating characteristic curve were associated with the five identified groups. Many of the abnormalities appear linked to low levels of folate, vitamin B12, and carnitine-conjugated molecules. CONCLUSIONS: Mothers of children with ASD have many significantly different metabolite levels compared to mothers of typically developing children at 2-5 years after birth.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno del Espectro Autista Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno del Espectro Autista Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans Idioma: En Revista: BMC Pediatr Asunto de la revista: PEDIATRIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido