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FZD5 contributes to TNBC proliferation, DNA damage repair and stemness.
Sun, Yu; Wang, Zhuo; Na, Lei; Dong, Dan; Wang, Wei; Zhao, Chenghai.
Afiliación
  • Sun Y; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
  • Wang Z; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
  • Na L; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
  • Dong D; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
  • Wang W; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. wangwei07@cmu.edu.cn.
  • Zhao C; Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China. chzhao@cmu.edu.cn.
Cell Death Dis ; 11(12): 1060, 2020 12 12.
Article en En | MEDLINE | ID: mdl-33311446
Chemotherapy currently remains the standard treatment for triple-negative breast cancer (TNBC). However, TNBC frequently develop chemoresistance, which is responsible for cancer recurrence and distal metastasis. Both DNA damage repair and stemness are related to chemoresistance. FZD5, a member in Frizzled family, was identified to be preferentially expressed in TNBC, and associated with unfavorable prognosis. Loss and gain of function studies revealed that FZD5 contributed to TNBC cell G1/S transition, DNA replication, DNA damage repair, survival, and stemness. Mechanistically, transcription factor FOXM1, which promoted BRCA1 and BIRC5 transcription, acted as a downstream effecter of FZD5 signaling. FOXM1 overexpression in FZD5-deficient/low TNBC cells induced FZD5-associated phenotype. Finally, Wnt7B, a specific ligand for FZD5, was shown to be involved in cell proliferation, DNA damage repair, and stemness. Taken together, FZD5 is a novel target for the development of therapeutic strategies to overcome chemoresistance and prevent recurrence in TNBC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Daño del ADN / Reparación del ADN / Receptores Frizzled / Neoplasias de la Mama Triple Negativas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Daño del ADN / Reparación del ADN / Receptores Frizzled / Neoplasias de la Mama Triple Negativas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Cell Death Dis Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido