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A chemical-specific adjustment factor for human interindividual differences in kinetics for glutamates (E620-625).
Rietjens, Ivonne McM; Tanaka, Takayuki; Masuzawa, Yoko; Nakamura, Hidehiro; Ishizaka, Yuko; Teoh, Keng Ngee.
Afiliación
  • Rietjens IM; Division of Toxicology, Wageningen University, Stippeneng 4, 6708, WE, Wageningen, the Netherlands. Electronic address: ivonne.rietjens@wur.nl.
  • Tanaka T; Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Japan.
  • Masuzawa Y; Quality Assurance Department, Ajinomoto Co., Inc., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo, Japan; International Glutamate Technical Committee (IGTC), Avenue de Turvueren 188a, B-1150, Brussels, Belgium.
  • Nakamura H; Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kawasaki, Japan.
  • Ishizaka Y; Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, 1 Kanda, Izumicho, Chiyoda-ku, Tokyo, Japan.
  • Teoh KN; Quality Assurance Department, Ajinomoto Co., Inc., 15-1, Kyobashi 1-chome, Chuo-ku, Tokyo, Japan; International Glutamate Technical Committee (IGTC), Avenue de Turvueren 188a, B-1150, Brussels, Belgium.
Food Chem Toxicol ; 147: 111910, 2021 Jan.
Article en En | MEDLINE | ID: mdl-33309877
Use of a default methodology for establishment of a health-based guidance value (HBGV) resulted in a group acceptable daily intake (ADI) for glutamates (E620-625) below the normal dietary glutamate intake, and also lower than the intake of free glutamate by breast fed babies. Use of a chemical-specific adjustment factor (CSAF) may overcome this problem. The present study investigates the interindividual human variability in glutamate plasma and brain levels in order to define a CSAF for the interindividual variation in kinetics, a HKAF, for glutamates. Human clinical data on plasma glutamate levels available from different groups of subjects at Mitsui Memorial Hospital as well as literature data on plasma and brain-related glutamate levels were collected and analysed. The median HKAF value obtained amounted to 2.62-2.74 to 2.33-2.52 for plasma derived values and to 1.68-1.81 for brain derived values. Combining these values with the CSAF for the interspecies differences in kinetics of 1 and the default factors for interspecies and interindividual differences in dynamics of 2.5 and 3.16 results in an overall CSAF of 16-20. Using this CSAF will result in a HBGV for glutamate that is no longer below the acceptable range of oral intake (AROI).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glutamatos / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Food Chem Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glutamatos / Modelos Biológicos Tipo de estudio: Guideline / Prognostic_studies Límite: Humans Idioma: En Revista: Food Chem Toxicol Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido