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Effect of therapeutic plasma exchange on phenytoin plasma concentration in patients receiving intravenous fosphenytoin therapy.
Nishida, S; Hayashi, Y; Hirai, K; Takekoshi, A; Yamada, Y; Kobayashi, R; Shimizu, S; Niwa, T; Hayashi, H; Shimohata, T; Sugiyama, T; Suzuki, A.
Afiliación
  • Nishida S; Department of Pharmacy, Gifu University Hospital, Gifu, Japan.
  • Hayashi Y; Departments of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Hirai K; Department of Clinical Pharmacology & Genetics, School of Pharmaceutical Sciences, University of Shizuoka, Gifu, Japan.
  • Takekoshi A; Departments of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Yamada Y; Department of Pharmacy, Gifu University Hospital, Gifu, Japan.
  • Kobayashi R; Department of Pharmacy, Gifu University Hospital, Gifu, Japan.
  • Shimizu S; Department of Pharmacy, Gifu University Hospital, Gifu, Japan.
  • Niwa T; Department of Pharmacy, Gifu University Hospital, Gifu, Japan.
  • Hayashi H; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, Japan.
  • Shimohata T; Departments of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • Sugiyama T; Laboratory of Pharmacy Practice and Social Science, Gifu Pharmaceutical University, Gifu, Japan.
  • Suzuki A; Department of Pharmacy, Gifu University Hospital, Gifu, Japan;, Email: akio@gifu-u.ac.jp.
Pharmazie ; 75(10): 488-490, 2020 10 01.
Article en En | MEDLINE | ID: mdl-33305722
We report for patients with encephalitis treated with plasma exchange (PE) and fosphenytoin. In patient 1, phenytoin levels decreased on the maintenance dose, and the phenytoin concentration was <10 µg/mL on day 12 of administration. In patient 2, the phenytoin levels was <10 µg/mL on day 4. Increasing the fosphenytoin dose pushed the phenytoin level into therapeutic range. There were no differences between the areas under the concentration-time curve of phenytoin with and without PE. We previously reported a decline in phenytoin levels after prolonged use of fosphenytoin. Therefore, dose adjustment of fosphenytoin in patients undergoing PE may be unnecessary.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenitoína / Intercambio Plasmático / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Adolescent / Female / Humans Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenitoína / Intercambio Plasmático / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Adolescent / Female / Humans Idioma: En Revista: Pharmazie Asunto de la revista: FARMACIA Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Alemania