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IL-6 and other biomarkers as predictors of severity in COVID-19.
Broman, N; Rantasärkkä, K; Feuth, T; Valtonen, M; Waris, M; Hohenthal, U; Rintala, E; Karlsson, A; Marttila, H; Peltola, V; Vuorinen, T; Oksi, J.
Afiliación
  • Broman N; Department of Infectious Diseases, Turku University Hospital, Turku, Finland.
  • Rantasärkkä K; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Feuth T; Department of Pulmonary Diseases, Turku University Hospital and Department of Pulmonary Diseases and Clinical Allergology, University of Turku, Turku, Finland.
  • Valtonen M; Department of Anaesthesia and Intensive Care, Turku University Hospital, Turku, Finland.
  • Waris M; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Hohenthal U; Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland.
  • Rintala E; Department of Hospital Hygiene and Infection Control, Turku University Hospital, Turku, Finland.
  • Karlsson A; Auria Biobank, Turku University Hospital and University of Turku, Turku, Finland.
  • Marttila H; Department of Hospital Hygiene and Infection Control, Turku University Hospital, Turku, Finland.
  • Peltola V; Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  • Vuorinen T; Department of Clinical Microbiology, Turku University Hospital and Institute of Biomedicine, University of Turku, Turku, Finland.
  • Oksi J; Department of Infectious Diseases, Turku University Hospital and University of Turku, Turku, Finland.
Ann Med ; 53(1): 410-412, 2021 12.
Article en En | MEDLINE | ID: mdl-33305624
OBJECTIVE: Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by different biomarkers. METHODS: We studied markers of inflammation and coagulation as recorded in 29 patients on admission to the hospital in order to identify markers of severe COVID-19 and need of ICU. RESULTS: Patients who were eventually admitted to ICU displayed significantly higher serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and procalcitonin. No statistical differences were found between the groups in median levels of lymphocytes, D-dimer or ferritin. CONCLUSIONS: IL-6 and CRP were the strongest predictors of severity in hospitalized patients with COVID-19.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interleucina-6 / COVID-19 Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Ann Med Asunto de la revista: MEDICINA Año: 2021 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido