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Echolalia in patients with primary progressive aphasia.
Ota, Shoko; Kanno, Shigenori; Morita, Ayumi; Narita, Wataru; Kawakami, Nobuko; Kakinuma, Kazuo; Saito, Yumiko; Kobayashi, Erena; Baba, Toru; Iizuka, Osamu; Nishio, Yoshiyuki; Matsuda, Minoru; Odagiri, Hayato; Endo, Keiko; Takanami, Kentaro; Mori, Etsuro; Suzuki, Kyoko.
Afiliación
  • Ota S; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kanno S; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Morita A; Department of Rehabilitation, Tohoku University Hospital, Sendai, Japan.
  • Narita W; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kawakami N; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kakinuma K; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Saito Y; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kobayashi E; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Baba T; Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
  • Iizuka O; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Nishio Y; Department of Neurology, Sendai Nishitaga Hospital, Sendai, Japan.
  • Matsuda M; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Odagiri H; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Endo K; Department of General Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Setagaya, Japan.
  • Takanami K; Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Mori E; Seizankai Group, Izuminomori Clinic, Sendai, Japan.
  • Suzuki K; Department of Radiology, Tohoku University Hospital, Sendai, Japan.
Eur J Neurol ; 28(4): 1113-1122, 2021 04.
Article en En | MEDLINE | ID: mdl-33305428
OBJECTIVE: This study aimed to examine echolalia and its related symptoms and brain lesions in primary progressive aphasia (PPA). METHODS: Forty-five patients with PPA were included: 19 nonfluent/agrammatic variant PPA (nfvPPA), 5 semantic variant PPA, 7 logopenic variant PPA, and 14 unclassified PPA patients. We detected echolalia in unstructured conversations. An evaluation of language function and the presence of parkinsonism, grasp reflex, imitation behaviour, and disinhibition were assessed. We also measured regional cerebral blood flow (rCBF) using single-photon emission computed tomography. RESULTS: Echolalia was observed in 12 nfvPPA and 2 unclassified PPA patients. All patients showed mitigated echolalia. We compared nfvPPA patients with echolalia (echolalia group) to those without echolalia (non-echolalia group). The median age of the echolalia group was significantly lower than that of the non-echolalia group, and the echolalia group showed a significantly worse auditory comprehension performance than the non-echolalia group. In contrast, the performance of repetition tasks was not different between the two groups. The prevalence of imitation behaviour in the echolalia group was significantly higher than that in the non-echolalia group. The rCBFs in the bilateral pre-supplementary motor area and bilateral middle cingulate cortex in the echolalia group were significantly lower than those in the non-echolalia group. CONCLUSIONS: These findings suggest that echolalia is characteristic of nfvPPA patients with impaired comprehension. Reduced inhibition of the medial frontal cortex with release activity of the anterior perisylvian area account for the emergence of echolalia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Afasia / Afasia Progresiva Primaria / Afasia Progresiva Primaria no Fluente Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Afasia / Afasia Progresiva Primaria / Afasia Progresiva Primaria no Fluente Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido