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Well-differentiated neuroendocrine tumors of the lower urinary tract: biologic behavior of a rare entity.
Rodriguez Pena, Maria Del Carmen; Salles, Daniela C; Epstein, Jonathan I; Canete-Portillo, Sofia; Tregnago, Aline C; Ramirez, July; Meliti, Abdelrazak; Netto, George J.
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  • Rodriguez Pena MDC; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
  • Salles DC; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
  • Epstein JI; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
  • Canete-Portillo S; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
  • Tregnago AC; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
  • Ramirez J; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
  • Meliti A; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA.
  • Netto GJ; Department of Pathology, Johns Hopkins Hospital, Baltimore, MD, 21287, USA; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. Electronic address: gnetto@uabmc.edu.
Hum Pathol ; 109: 53-58, 2021 03.
Article en En | MEDLINE | ID: mdl-33301750
The spectrum of neuroendocrine (NE) tumors in the genitourinary tract ranges from the aggressive large and small cell carcinomas to the often benign paraganglioma and well-differentiated neuroendocrine tumor (WD-NET). At least 15 pure lower urinary tract (LUT) WD-NETs have been described. Owing to the rarity of WD-NET in the LUT and the limited number of reported cases, a better definition of their biologic long-term behavior is warranted. Herein, we aim to describe 10 new cases of WD-NET arising in the LUT and expand on follow-up findings. Ten consultation cases were identified and included 6 men and 4 women who ranged from 45 to 73 years of age. Seven cases arose in the bladder with one located in the bladder neck, 1 arose in the prostatic urethra, 1 arose in the female urethra, and 1 arose in the left ureteral orifice. All lesions were confined to the lamina propria, and tumor architecture was pseudoglandular in all cases. Associated cystitis cystica et glandularis was identified in 5 cases; urothelial papilloma and florid von Brunn's nests were found in 2 additional cases. Immunohistochemical staining for synaptophysin and chromogranin was diffusely positive in 9 cases and focal in 1 case, and the Ki-67 proliferation index was 5% or less in all tumors. Follow-up ranged from 37 to 137 months (mean = 82; median = 77), and there was no evidence of residual disease or recurrence in any of the 10 patients during the follow-up period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Tumores Neuroendocrinos / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Tumores Neuroendocrinos / Recurrencia Local de Neoplasia Tipo de estudio: Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos