High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene.

Hu, Shanshan; Su, Dongmei; Sun, Lei; Wang, Zhongying; Guan, Lina; Liu, Shanhe; Zhao, Baowen; Liu, Yong; Shi, Cuige; Yu, Jianbo; Ma, Xu

Hu, Shanshan; Su, Dongmei; Sun, Lei; Wang, Zhongying; Guan, Lina; Liu, Shanhe; Zhao, Baowen; Liu, Yong; Shi, Cuige; Yu, Jianbo; Ma, Xu.

Afiliación

Hu S; Hongqi Hospital of Mudanjiang Medical College, 5 Tongxiang Road, Mudanjiang, 157011, Heilongjiang, China. hushanshan19830219@126.com.
Su D; Department of Immunology, Basic Medical College of Harbin Medical University, Harbin, 150081, Heilongjiang, China. hushanshan19830219@126.com.
Sun L; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China.
Wang Z; Graduate School, Peking Union Medical College, Beijing, 100081, China.
Guan L; Hongqi Hospital of Mudanjiang Medical College, 5 Tongxiang Road, Mudanjiang, 157011, Heilongjiang, China.
Liu S; Hongqi Hospital of Mudanjiang Medical College, 5 Tongxiang Road, Mudanjiang, 157011, Heilongjiang, China.
Zhao B; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China.
Liu Y; Hongqi Hospital of Mudanjiang Medical College, 5 Tongxiang Road, Mudanjiang, 157011, Heilongjiang, China.
Shi C; Hongqi Hospital of Mudanjiang Medical College, 5 Tongxiang Road, Mudanjiang, 157011, Heilongjiang, China.
Yu J; Medical Research Center of Mudanjiang Medical College, Mudanjiang, 157011, Heilongjiang, China.
Ma X; Department of Genetics, National Research Institute for Family Planning, Health Department, Beijing, 100081, China.

Mol Med ; 26(1): 124, 2020 12 09.

Article en En | MEDLINE | ID: mdl-33297931

Asunto(s)

Apoptosis/genética; Catarata/etiología; Células Epiteliales/metabolismo; Proteína p53 Supresora de Tumor/genética; Quinasas Asociadas a rho/genética; Animales; Apoptosis/efectos de los fármacos; Catarata/metabolismo; Catarata/patología; Línea Celular; Modelos Animales de Enfermedad; Células Epiteliales/efectos de los fármacos; Peróxido de Hidrógeno/metabolismo; Peróxido de Hidrógeno/farmacología; Inmunohistoquímica; Ratones; Fosforilación; Proteína p53 Supresora de Tumor/metabolismo; Quinasas Asociadas a rho/metabolismo

Palabras clave

Age-related cataract; Apoptosis; Lens epithelial cells; P53; ROCK1

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Catarata / Proteína p53 Supresora de Tumor / Apoptosis / Células Epiteliales / Quinasas Asociadas a rho Límite: Animals Idioma: En Revista: Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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