The ZATT-TOP2A-PICH Axis Drives Extensive Replication Fork Reversal to Promote Genome Stability.

Tian, Tian; Bu, Min; Chen, Xu; Ding, Linli; Yang, Yulan; Han, Jinhua; Feng, Xin-Hua; Xu, Pinglong; Liu, Ting; Ying, Songmin; Lei, Yang; Li, Qing; Huang, Jun

Tian, Tian; Bu, Min; Chen, Xu; Ding, Linli; Yang, Yulan; Han, Jinhua; Feng, Xin-Hua; Xu, Pinglong; Liu, Ting; Ying, Songmin; Lei, Yang; Li, Qing; Huang, Jun.

Afiliación

Tian T; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Bu M; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Chen X; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Ding L; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Yang Y; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Han J; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Feng XH; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Xu P; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Liu T; Department of Cell Biology and Department of General Surgery of Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Ying S; Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Lei Y; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Li Q; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.
Huang J; The MOE Key Laboratory of Biosystems Homeostasis & Protection, Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China. Electronic address: jhuang@zju.edu

Mol Cell ; 81(1): 198-211.e6, 2021 01 07.

Article en En | MEDLINE | ID: mdl-33296677

Asunto(s)

ADN Helicasas/metabolismo; Replicación del ADN; ADN-Topoisomerasas de Tipo II/metabolismo; Genoma Humano; Inestabilidad Genómica; Proteínas de Unión a Poli-ADP-Ribosa/metabolismo; ADN Helicasas/genética; ADN-Topoisomerasas de Tipo II/genética; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Células HEK293; Células HeLa; Humanos; Proteínas de Unión a Poli-ADP-Ribosa/genética; Factores de Transcripción/genética; Factores de Transcripción/metabolismo

Palabras clave

DNA topoisomerase; DNA translocase; SUMO E3 ligase; SUMOylation; genome instability; replication fork restart; replication fork reversal

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Genoma Humano / ADN-Topoisomerasas de Tipo II / ADN Helicasas / Inestabilidad Genómica / Replicación del ADN / Proteínas de Unión a Poli-ADP-Ribosa Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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