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Relating Response Inhibition, Brain Connectivity, and Freezing of Gait in People with Parkinson's Disease.
Peterson, Daniel S; Smulders, Katrijn; Mancini, Martina; Nutt, John G; Horak, Fay B; Fling, Brett W.
Afiliación
  • Peterson DS; College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
  • Smulders K; VA Phoenix Health Care System, Phoenix, AZ, USA.
  • Mancini M; Department of Research, Sint Maartenskliniek, Nijmegen, the Netherlands.
  • Nutt JG; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
  • Horak FB; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
  • Fling BW; Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
J Int Neuropsychol Soc ; 27(7): 733-743, 2021 08.
Article en En | MEDLINE | ID: mdl-33292899
OBJECTIVE: Freezing of gait (FoG) in Parkinson's disease (PD) has been associated with response inhibition. However, the relationship between response inhibition, neural dysfunction, and PD remains unclear. We assessed response inhibition and microstructural integrity of brain regions involved in response inhibition [right hemisphere inferior frontal cortex (IFC), bilateral pre-supplementary motor areas (preSMA), and subthalamic nuclei (STN)] in PD subjects with and without FoG and elderly controls. METHOD: Twenty-one people with PD and FoG (PD-FoG), 18 without FoG (PD-noFoG), and 19 age-matched controls (HC) completed a Stop-Signal Task (SST) and MRI scan. Probabilistic fiber tractography assessed structural integrity (fractional anisotropy, FA) among IFC, preSMA, and STN regions. RESULTS: Stop-signal performance did not differ between PD and HC, nor between PD-FoG and PD-noFoG. Differences in white matter integrity were observed across groups (.001 < p < .064), but were restricted to PD versus HC groups; no differences in FA were observed between PD-FoG and PD-noFoG (p > .096). Interestingly, worse FoG was associated with higher (better) mean FA in the r-preSMA, (ß = .547, p = .015). Microstructural integrity of the r-IFC, r-preSMA, and r-STN tracts correlated with stop-signal performance in HC (p ≤ .019), but not people with PD. CONCLUSION: These results do not support inefficient response inhibition in PD-FoG. Those with PD exhibited white matter loss in the response inhibition network, but this was not associated with FoG, nor with response inhibition deficits, suggesting FoG-specific neural changes may occur outside the response inhibition network. As shown previously, white matter loss was associated with response inhibition in elderly controls, suggesting PD may disturb this relationship.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha Tipo de estudio: Etiology_studies Límite: Aged / Humans Idioma: En Revista: J Int Neuropsychol Soc Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Trastornos Neurológicos de la Marcha Tipo de estudio: Etiology_studies Límite: Aged / Humans Idioma: En Revista: J Int Neuropsychol Soc Asunto de la revista: NEUROLOGIA / PSICOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido