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Functional magnetic resonance brain imaging of imagined walking to study locomotor function after stroke.
Boyne, Pierce; Doren, Sarah; Scholl, Victoria; Staggs, Emily; Whitesel, Dustyn; Maloney, Thomas; Awosika, Oluwole; Kissela, Brett; Dunning, Kari; Vannest, Jennifer.
Afiliación
  • Boyne P; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA. Electronic address: Pierce.Boyne@uc.edu.
  • Doren S; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Scholl V; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Staggs E; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Whitesel D; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Maloney T; Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Awosika O; Department of Neurology and Rehabilitation Medicine, College of Medicine, University of Cincinnati, OH, USA.
  • Kissela B; Department of Neurology and Rehabilitation Medicine, College of Medicine, University of Cincinnati, OH, USA.
  • Dunning K; Department of Rehabilitation, Exercise and Nutrition Sciences, College of Allied Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
  • Vannest J; Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Communication Sciences and Disorders, College of Allied Health Sciences, University of Cincinnati, OH, USA.
Clin Neurophysiol ; 132(1): 167-177, 2021 01.
Article en En | MEDLINE | ID: mdl-33291023
OBJECTIVE: Imagined walking has yielded insights into normal locomotor control and could improve understanding of neurologic gait dysfunction. This study evaluated brain activation during imagined walking in chronic stroke. METHODS: Ten persons with stroke and 10 matched controls completed a walking test battery and a magnetic resonance imaging session including imagined walking and knee extension tasks. Brain activations were compared between tasks and groups. Associations between activations and composite gait score were also calculated, while controlling for lesion load. RESULTS: Stroke and worse gait score were each associated with lesser overall brain activation during knee extension but greater overall activation during imagined walking. During imagined walking, the stroke group significantly activated the primary motor cortex lower limb region and cerebellar locomotor region. Better walking function was associated with less activation of these regions and greater activation of medial superior frontal gyrus area 9. CONCLUSIONS: Compared with knee extension, imagined walking was less sensitive to stroke-related deficits in brain activation but better at revealing compensatory changes, some of which could be maladaptive. SIGNIFICANCE: The identified associations for imagined walking suggest potential neural mechanisms of locomotor adaptation after stroke, which could be useful for future intervention development and prognostication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Caminata / Accidente Cerebrovascular / Imaginación / Locomoción Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Caminata / Accidente Cerebrovascular / Imaginación / Locomoción Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Neurophysiol Asunto de la revista: NEUROLOGIA / PSICOFISIOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos