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Multicenter retrospective cohort study of the clinical significance of Staphylococcus lugdunensis isolated from a single blood culture set.
Hauser, Naomi; Kim, Justin J; Luethy, Paul M; Schmalzle, Sarah A; Bork, Jacqueline T.
Afiliación
  • Hauser N; University of Maryland Medical Center, Baltimore MD, USA. Electronic address: Naomi.hauser@gmail.com.
  • Kim JJ; University of Maryland Medical Center, Baltimore MD, USA.
  • Luethy PM; University of Maryland School of Medicine, Department of Pathology, Baltimore, MD, USA.
  • Schmalzle SA; Institute of Human Virology, University of Maryland School of Medicine, MD, USA; University of Maryland School of Medicine, Department of Medicine, Division of Infectious Disease, Baltimore MD, USA.
  • Bork JT; University of Maryland School of Medicine, Department of Medicine, Division of Infectious Disease, Baltimore MD, USA.
Diagn Microbiol Infect Dis ; 99(3): 115261, 2021 Mar.
Article en En | MEDLINE | ID: mdl-33290922
BACKGROUND: Staphylococcus lugdunensis is a coagulase negative Staphylococcus species and frequent human skin commensal with the potential for aggressive infection. Guidance surrounding S. lugdunensis bacteremia (SLB) from a single set of blood cultures is lacking. METHODS: A multicenter, retrospective cohort of patients with SLB from at least one blood culture set within the University of Maryland Medical System from 2015 to 2019 is presented. Objectives are to describe baseline characteristics, compare the clinical status and treatment course, and to evaluate the clinical outcomes among patients with SLB in single versus multiple sets. RESULTS: Thirty-six patients were included, 24 with one set of blood cultures positive for S lugdunensis and 12 with multiple sets. Baseline characteristics were similar between the groups, though patients with SLB in multiple sets were more commonly on hemodialysis (P = 0.029). Central lines were the most common source (17%). Most (97%) fulfilled systemic inflammatory response syndrome or Souvenir criteria, had an infectious focus on imaging, or had a second positive culture site. Most (78%) were treated as clinically significant. Patients with multiple positive sets were more commonly treated with antibiotics for >2 weeks (P = 0.02). CONCLUSIONS: SLB was rare and occurred more frequently as a single set of positive cultures. Patient characteristics and clinical courses were similar between single and multiple set groups. Given the potential severity of S. lugdunensis bacteremia it seems prudent to treat S. lugdunensis in a single blood culture as true bacteremia, pending larger studies and guidelines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Bacteriemia / Staphylococcus lugdunensis Tipo de estudio: Etiology_studies / Guideline / Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Bacteriemia / Staphylococcus lugdunensis Tipo de estudio: Etiology_studies / Guideline / Observational_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Diagn Microbiol Infect Dis Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos